《中国期刊全文数据库》收录期刊
《中国核心期刊（遴选）数据库》收录期刊
《中文科技期刊数据库》收录期刊
外科研究与新技术（中英文）

外科研究与新技术（中英文） ›› 2025, Vol. 14 ›› Issue (3): 230-233.doi: 10.3969/j.issn.2095-378X.2025.03.007

• 论著 • 上一篇    下一篇

奥赛利定联合丙泊酚应用于胃肠镜检查的量效关系研究

黄广用, 黄敏贞, 刘宝芸   

  1. 南方医科大学珠江医院三水医院麻醉科,广东 佛山 528100
  • 收稿日期:2025-05-07 出版日期:2025-09-28 发布日期:2025-10-17
  • 通讯作者: 刘宝芸,电子信箱：huanggyfsh80@163.com
  • 作者简介:黄广用(1980—),男,学士,副主任医师,从事临床麻醉科工作

A dose-response relationship study of oliceridine combined with propofol for gastrointestinal endoscopy

HUANG Guangyong, HUANG Minzhen, LIU Baoyun   

  1. Department of Anesthesiology, Sanshui Hospital, Zhujiang Hospital, Southern Medical University, Foshan 528100, Guangdong, China
  • Received:2025-05-07 Online:2025-09-28 Published:2025-10-17

PDF (PC)

66

摘要： 目的 探讨奥赛利定联合丙泊酚（血浆靶控浓度3 μg/mL）应用于无痛胃肠镜检查的半数有效剂量（ED50）和95%有效剂量（ED95）。方法 选取2024年7—12月在本院择期行无痛胃肠镜检查患者27例。所有患者均接受丙泊酚血浆靶控输注（TCI）3 μg/mL。采用改良Dixon序贯法确定奥赛利定剂量（初始1 mg,梯度0.1 mg）,根据前例患者反应（阳性：检查中出现咳嗽、干呕或目的性体动）调整剂量（阳性增,阴性减）,至7次反应交替后终止。采用Probit回归分析计算奥赛利定的ED50、ED95及95%置信区间（CI）。结果 奥赛利定联合丙泊酚（TCI 3 μg/mL）用于胃肠镜检查的ED50为0.829 mg（95%CI 0.509~1.053 mg）,ED95为1.176 mg（95%CI 0.997~4.936 mg）。结论 奥赛利定联合丙泊酚（TCI 3 μg/mL）用于胃肠镜检查时,抑制置入反应的奥赛利定ED95为1.176 mg,可为临床应用提供剂量参考。

关键词: 奥赛利定, 胃肠镜检查, 95%有效剂量, 半数有效剂量, 丙泊酚

Abstract: Objective To determine the median effective dose （ED50） and 95% effective dose （ED95） of oliceridine combined with propofol （plasma target-controlled concentration at 3 μg/mL） for painless gastrointestinal endoscopy. Methods A total of 27 patients scheduled for painless gastrointestinal endoscopy from July to December 2024 were enrolled. All patients received propofol via target-controlled infusion （TCI） at a plasma concentration of 3 μg/mL. The modified Dixon's up-and-down sequential method was used to determine the oliceridine dose （initial dose 1 mg,step size 0.1 mg）. The dose for each subsequent patient was adjusted based on the response of the previous patient （positive response： coughing, retching, or purposeful movement during endoscopy）, with an increase after a positive response and a decrease after a negative response. The study was terminated after 7 response crossovers. Probit regression analysis was used to calculate the ED50, ED95, and their 95% confidence intervals （CIs） for oliceridine. Results The ED50 of oliceridine combined with propofol （TCI 3 μg/mL） for gastrointestinal endoscopy was 0.829 mg （95%CI 0.509-1.053 mg）, and the ED95 was 1.176 mg （95%CI 0.997-4.936 mg）. Conclusion When oliceridine is combined with propofol （TCI 3 μg/mL） for gastrointestinal endoscopy, the ED95 of oliceridine to suppress the insertion response is 1.176 mg. This provides a dose reference for clinical application.

Key words: Oliceridine, Gastrointestinal endoscopy, 95% effective dose, Median effective dose, Propofol

中图分类号: