关键词: 舒芬太尼, 皮下自控镇痛, 癌痛, 镇痛效果, 生存质量

Abstract: Objective To investigate the effect of patient-controlled subcutaneous analgesia （PCSA） with sufentanil on analgesia and quality of life in patients with cancer pain at home. Methods A total of 85 patients with cancer pain who were admitted from March 2023 to March 2025 were selected and divided into a control group and an observation group according to the random number table method, with 45 cases in each group. Five cases dropped off in the observation group, and 40 cases were finally included in the observation group. Patients in the control group were treated with oral morphine for analgesia, and patients in the observation group were treated with sufentanil PCSA. The quality of life [Karnofsky performance scale （KPS）] and pain [numerical rating scale （NRS）] before and after treatment and the incidence of adverse reactions during treatment were compared between the two groups. Results After treatment, the NRS scores in both groups were lower than those before treatment （P<0.05）. The NRS score of the control group was higher than that of the observation group, and the KPS score was lower of the control group than that of the observation group （P<0.05）. The pain relief rate of the control group was 71.11%, which was lower than 95.00% of the observation group （P<0.05）. The incidence of adverse reactions after treatment in the observation group was 30.00%, which was significantly lower than 53.33% in the control group （P<0.05）. Conclusion Sufentanil PCSA has a good analgesic effect on patients with cancer pain at home, can improve the quality of life of patients, and has high safety.

Key words: Sufentanil, Subcutaneous self-controlled analgesia, Cancer pain, Analgesic effect, Quality of life