目的 观察复方三黄液应用于湿热瘀阻型慢性难愈性创面（CRW）创基准备的临床疗效。方法 选取2018年1月—2022年6月收治住院的湿热瘀阻型CRW患者95例,采用随机数字表法分为观察组（49例）和对照组（46例）。两组均予基础治疗及手术清创治疗,术后对照组予常规外科换药,观察组在此基础上予复方三黄液创面湿敷。观察两组创面愈合面积比、创面愈合深度比、创面完全愈合患者比、创面愈合时间、创面病原菌阳性率、再手术率、术后Bates-Jensen伤口评估工具（BWAT）评分及中医证候疗效评定。结果 观察组的创面愈合面积比、深度比及创面完全愈合患者比均高于对照组,差异有统计学意义（P<0.05）;在创面愈合时间、创面病原菌阳性率及再手术率上,观察组均低于对照组,差异有统计学意义（P<0.05）;观察组术后BWAT评分及中医证候疗效优于对照组,差异有统计学意义（P<0.05）。结论 复方三黄液应用于湿热瘀阻型CRW创基准备中,能有效促进创面修复,缩短病程,减少创面感染,避免多次手术,临床疗效良好,值得进一步推广应用。
Objective To observe the clinical efficacy of compound Sanhuang liquid in wound bed preparation for chronic refractory wounds （CRW） of damp-heat and blood-stasis syndrome. Methods A total of 95 patients with CRW of damp-heat and blood-stasis syndrome from January 2018 to June 2022 were selected and randomly divided into an observation group （49 cases） and a control group （46 cases） by random number table method. Both groups received basic treatment and surgical debridement. After surgery, the control group received routine surgical dressing changes, and on this basis, the observation group received wound wet dressing with compound Sanhuang liquid. Ratios of wound to healing area and depth, the proportion of patients with complete wound healing, wound healing time, wound pathogen positive rate, reoperation rate, postoperative Bates-Jensen wound assessment tool （BWAT） score, and traditional Chinese medicine syndrome efficacy evaluation were compared between the two groups of patients. Results The ratios of wound to healing area and depth and the proportion of patients with complete wound healing in the observation group were higher than those in the control group （P<0.05）. The wound healing time, wound pathogen positive rate, and reoperation rate in the observation group were lower than those in the control group （P<0.05）. The observation group had better postoperative BWAT scores and traditional Chinese medicine syndrome efficacy than the control group （P<0.05）. Conclusion The application of compound Sanhuang liquid in the wound bed preparation for CRW of damp-heat and blood-stasis syndrome can effectively promote wound repair, shorten the course of disease, reduce the incidence of wound infection, and avoid multiple surgeries, showing good clinical efficacy. It is worthy of further promotion and application.
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