目的 探讨神经阻滞联合脉冲射频用于治疗带状疱疹后神经痛（PHN）的疗效。方法 选取2022年1月—2024年12月接受治疗的100例PHN患者作为研究对象,随机分为神经阻滞组（椎旁神经阻滞）和联合治疗组（椎旁神经阻滞联合脊神经脉冲射频）,每组50例,对比分析两组治疗效果。结果 治疗前,两组间视觉模拟评分法（VAS）、疼痛评级指数（PRI）、现有疼痛强度（PPI）评分比较,差异均无统计学意义（P>0.05）;治疗后不同时间点（7 d、30 d）,两组VAS、PRI、PPI评分均显著低于治疗前（P<0.05）,且联合治疗组上述评分均显著低于神经阻滞组（P<0.05）。治疗前,两组间焦虑自评量表（SAS）、抑郁自评量表（SDS）、匹兹堡睡眠质量指数（PSQI）、健康调查量表36（SF-36）评分比较,差异均无统计学意义（P>0.05）;治疗后30 d,两组SAS、SDS、PSQI、SF-36评分均较治疗前明显改善（SAS、SDS、PSQI评分降低,SF-36评分升高）,差异均有统计学意义（P<0.05）,且联合治疗组上述评分均显著优于神经阻滞组（P<0.05）。联合治疗组治疗总有效率显著高于神经阻滞组（P<0.05）。结论 神经阻滞联合脉冲射频用于治疗PHN可显著改善患者疼痛并提升疗效,符合临床需求,值得推广。

Objective To investigate the efficacy of nerve block combined with pulsed radiofrequency in the treatment of postherpetic neuralgia （PHN）. Methods A total of 100 PHN patients treated from January 2022 to December 2024 were selected as research subjects and randomly divided into a nerve block group （paravertebral nerve block） and a combined treatment group （paravertebral nerve block combined with pulsed radiofrequency）, with 50 cases in each group. The effects between the two groups were compared. Results Before treatment, there was no significant difference in visual analog scale （VAS）, pain rating index （PRI）, and present pain intensity （PPI） scores between the two groups （P>0.05）. The VAS, PRI, and PPI scores of both groups were significantly reduced after treatment （7 d and 30 d） （P<0.05）, and the scores in the combined treatment group were lower than those in the nerve block group （P<0.05）. Before treatment, there were no significant differences in self-rating anxiety scale （SAS）, self-rating depression scale （SDS）, Pittsburgh sleep quality index （PSQI）, and short-form 36 （SF-36） scores between the two groups （P>0.05）. At 30 d after treatment, the SAS, SDS, PSQI, and SF-36 scores of the two groups were significantly improved （SAS, SDS, and PSQI scores were reduced, while SF-36 scores were imcreased） （P<0.05）, and the scores in the combined treatment group were significantly better than those in the nerve block group （P<0.05）. The total effective rate of treatment of the combined treatment group was significantly higher than that of the nerve block group （P<0.05）. Conclusion Nerve block combined with pulse radiofrequency in the treatment of PHN can significantly alleviate pain of patients and improve treatment efficacy, which meets clinical needs and can be popularized.