目的 探讨联合应用针刀、手法松解术治疗早中期膝骨关节炎（KOA）顽固性疼痛患者的效果。方法 选择2023年1月—2025年1月收治的80例早中期KOA顽固性疼痛患者,采用随机数字表法分为对照组（40例）和观察组（40例）。对照组单用针刀治疗,观察组联用针刀、手法松解术治疗,比较各组疼痛评分、膝关节功能评分、治疗效果、炎症因子水平、不良反应发生率、疾病复发率。结果 治疗后,观察组各项疼痛评分、膝关节功能各项评分均低于对照组（P<0.05）,治疗有效率大于对照组（P<0.05）,炎症因子水平低于对照组（P<0.05）,复发率小于对照组（P<0.05）,但不良反应率与对照组差异无统计学意义（P>0.05）。结论 联用针刀、手法松解术可安全有效治疗早中期KOA顽固性疼痛,改善疼痛症状与关节功能,抑制炎症反应,降低疾病复发率。

Objective To study the therapeutic effect of acupotomy and manual release on intractable pain of knee osteoarthritis （KOA） in early and middle stages. Methods A total of 80 patients with intractable pain of KOA in early and middle stages from January 2023 to January 2025 were selected and randomly divided into a control group （40 cases） and an observation group （40 cases）. The control group was treated with acupotomy alone, while the observation group was treated with acupotomy and manual release. The pain indicators, knee joint function, treatment effect, inflammatory factors, adverse reaction incidence, and recurrence between the two groups were compared. Results After treatment, the pain indicator scores and knee joint function scores of the observation group were lower than those of the control group （P<0.05）, the effective rate of treatment was higher （P<0.05）, the inflammatory factor levels were lower （P<0.05）, and the recurrence rate was lower （P<0.05）, but there was no difference in the adverse reaction rate between the two groups （P>0.05）. Conclusion The combination of acupotomy and manual release can safely and effectively treat intractable pain of KOA in early and middle stages, improve pain symptoms and joint function, inhibit inflammatory reaction, and reduce the recurrence rate of the disease.