目的 研究以神经信号通路调控为核心的阶段性康复训练对全膝关节置换术患者疼痛及关节活动度的影响。方法 选取2021年6月—2025年6月期间收治的全膝关节置换术患者68例,按照随机数字表法分为观察组与对照组,每组各34例。对照组采取常规康复治疗,观察组采取以调控神经信号通路为核心的阶段性康复训练,对比两组患者的疼痛度视觉模拟评分法（VAS）评分及关节活动度Fugl-Meyer运动功能评定（FMA）。结果 治疗后,两组膝关节功能水平显著升高,VAS评分显著降低,运动功能积分与疼痛积分显著升高,且观察组各指标水平改善优于对照组（P<0.05）。结论 相较于常规康复,以调控神经信号通路为核心的阶段性康复训练可更有效地缓解全膝关节置换术患者的术后疼痛,改善关节活动度与功能,促进康复。

Objective To investigate the effects of phased rehabilitation training centered on modulating neural signaling pathways on pain and joint range of motion in total knee arthroplasty patients. Methods Sixty-eight patients undergoing total knee arthroplasty admitted between June 2021 and June 2025 were randomly assigned to an observation group （n=34） and a control group （n=34）. The control group received conventional rehabilitation therapy, while the observation group underwent phased rehabilitation training centered on regulating neural signaling pathways. Pain visual analog scale （VAS） score and joint range of motion Fugl-Meyer assessment （FMA） were compared between the two groups. Results After treatment, both groups demonstrated significantly improved knee joint function scores, reduced VAS scores, along with increased motor function and joint pain scores. The observation group exhibited superior improvements across all metrics compared to the control group （P<0.05）. Conclusion Compared to conventional rehabilitation, phased rehabilitation training centered on regulating neural signaling pathways may more effectively alleviate postoperative pain, enhance joint range of motion and function, and promote recovery in total knee arthroplasty patients.