[摘要] 目的 探讨雌激素受体（ER）阴性表达的浸润性乳腺癌PR、HER-2、Ki-67的表达情况与临床病理特征的关系。方法 选取1339例浸润性乳腺癌，其中ER阴性乳腺癌403例，回顾性分析PR、HER-2、Ki-67的表达状况及其间的相关性，以及PR、HER-2、Ki-67的表达与临床病理特征关系。结果 PR、HER-2和Ki-67的阳性表达率分别为8.9%（36/403）、26.8%（108/403）和98.3%（396/403）。PR与患者年龄、肿瘤大小、P53表达有统计学意义（P <0.05），与组织学分级、有无淋巴结转移无统计学意义（P >0.05）。而HER-2与各项临床病理指标均有统计学意义（P <0.05）。 Ki-67表达与P53表达、淋巴结转移有关（P <0.05），与患者年龄、肿瘤大小及组织学分级无关（P >0.05）。PR、HER-2、Ki-67三者间表达呈正相关，其中Ki-67与HER-2表达呈高度正相关(r =0.941，P =0.000)。结论 ER阴性乳腺癌HER-2表达与临床病理特征有关。Ki-67可作为预测HER-2表达状况的重要指标。

[Abstract] Objective To investigate the relations between the gene expression of PR, HER-2 and Ki-67 in invasive ductal breast cancer with ER negative and clinical pathological indexes. Methods One thousand three hundred thirty nine cases with invasive breast cancer were selected. Among them, there were 403 cases with ER negative. PR, HER-2 and Ki-67 expression were analysed by the Spearman rank correlation. At the same time, relations between PR, HER-2 and Ki-67 expression and clinic indexes were retrospectively analysed. Results The positive rates of PR, HER-2 and Ki-67 were 8.9%（36/403）、26.8%（108/403）and 98.3%（396/403）, respectively. The expression of PR had statistical differences between age, tumor sizes and the expression of P53 (P <0.05), and had not statistical differences in histologic grade and lymph node metastasis (P >0.05). However, the expression of HER-2 was significantly statistical differences in clinic indexes (P <0.05). Moreover, the expressions between PR, HER-2 and Ki-67 were also correlated. Finally, the expressions between Ki-67 and HER-2 were significantly correlative(r =0.941，P =0.000). Conclusion The expressions of HER-2 are related with clinical pathological features in breast cancer with ER negative. The expression of Ki-67 can be regarded as an important index for the expression condition of HER-2.