骨折水疱（fracture blisters）是由于骨折创伤导致的局部表皮与真皮间，因水肿液的积聚而出现的分离和表皮坏死。骨折水疱可以是新鲜的清亮浆液，也可以是陈旧的暗红血液。骨折水疱的出现，导致皮肤完整性的破坏，可能迫使医生更改最佳和最终的治疗方案、延迟手术时间，亦可能引起伤口感染、延迟愈合，并最终妨碍患者的痊愈过程。本文对骨折水疱的发生率、病理、发生机制、治疗与预防方法等做一综述。

Fracture blisters are resulted from fracture trauma with large strains applied to the skin during the initial fracture deformation, causing a cleavage injury at the dermo-epidermal junction. There are two types of fracture blisters: clear-filled and blood-filled. Fracture blisters may significantly alter the ideal and/or the final treatment strategy, delay operation, increase wound infection and the final recovery of the patient. This paper reviews the literatures including its prevalence, pathology, mechanisms, prevention and treatment. However, no consensus on blister management was achieved.