目的 探讨幽门螺杆菌感染与肠溶阿司匹林及氯吡格雷引起消化道出血的关系。方法 选择2012年1月到2014年1月我院门诊或住院服用肠溶阿司匹林或氯吡格雷并且进行Hp检测的病人1009人，其中肠溶阿司匹林组478人，氯吡格雷组531人，每组根据Hp检测结果再分为Hp阴性组和Hp阳性组，观察上消化道出血情况。结果 肠溶阿司匹林组和氯吡格雷组Hp阳性患者上消化道出血比例均明显高于Hp阴性组（P＜0.05）。结论 根治幽门螺杆菌有利于降低肠溶阿斯匹林和氯吡格雷引起消化道出血的风险。

Objective This study was to investigate the Relationship between Helicobactor Pylori infection and upper gastrointestinal hemorrhage caused by anti platelet therapy. Methods 565 patients taking enteric-coated aspilin and 531 patients taking clopidogrel in our hospital from January 2012 to Junuary 2014 were studyed. All patients were given Hp testing and divided into Hp-positive group and Hp-negative group. Rusults We found that the Hp-positive groups have the more possibility of bleeding than the Hp-negative groups（P＜0.05）. Conclusion Eradication of Helicobacter pylori is helpful to reduce the risk of the gastrointestinal tract bleeding.