目的 探析膝关节软骨全层缺损病人进行关节镜下微骨折术疗法的临床效果观察。方法 入选我院2013年5月至2014年4月膝关节软骨全层缺损病人90例，根据随机数字表法分为对照组和实验组，每组45例，实验组进行关节镜下微骨折术疗法，对照组进行关节清理术，比较两组的临床效果；术后随访半年，比较两组治疗前后的HSS膝关节功能评分、Tegner运动能力评分情况。结果 实验组的临床有效率为91.1%，对照组的临床有效率为71.1%，差异有统计学意义（P<0.05）；两组治疗后的HSS膝关节功能评分、Tegner运动能力评分情况均有改善，但实验组治疗后的HSS膝关节功能评分、Tegner运动能力评分显著优于对照组，差异有统计学意义（P<0.05）。结论 膝关节软骨全层缺损病人进行关节镜下微骨折术疗法，可显著改善病人的膝关节活动能力及功能评分，临床效果确切，值得临床推广。

[Abstract] Objective:To explore the clinical effect of arthroscopic microfracture in the repair of full-thickness chondral defects of knee. Method:90 patients with full-thickness chondral defects of knee treated from May 2013 to April 2014 in our hospital were selected and randomly divided into control group and test group, 45 cases each group. The test group adopted the arthroscopic microfracture and control group adopted the articular debridement. The clinical effect of two groups was compared. After 6m of follow-up visits, HSS of knee function and Tegner score of athletic ability of two groups before and after treatment was compared. Result:The clinical effective rate of test group (91.1%) was higher than that of control group (71.1%) (P＜0.05); HSS of knee function and Tegner score of athletic ability of two groups after treatment was improved. However, HSS of knee function and Tegner score of athletic ability of test group was better than that of control group (P＜0.05).Conclusion: For patients with full-thickness chondral defects of knee, the arthroscopic microfracture has an obvious effect and can greatly improve the articular activity and function scores. It is worthy of clinical promotion.