目的
研究趋化因子受体4(chemokine receptor4，CXCR4)在结肠癌组织中的表达情况，分析其与临床病理特点及预后的关系。
方法
选择2013年来南通大学第二附属医院普外科施行的结肠癌手术组织标本及对应标本的癌旁正常结肠组织标本，应用免疫组织化学方法染色分析检测不同临床分期的人结肠癌组织（50例）及癌旁正常结肠组织（10例）中CXCR4的表达情况，分析CXCR4表达水平与患者临床病理特征及预后的关系。
结果
结肠癌组中CXCR4的阳性表达率为（72.0%，36/50）明显高于癌旁正常组织组（10%，1/10），结果具有统计学意义（P<0.05）。CXCR4与在不同性别、年龄、肿瘤部位、肿瘤大小、组织学类型的结肠癌患者中的表达并无明显差异（P>0.05）。但在肿瘤侵犯结肠浆膜层组、有淋巴结转移组，TNM分期高组 CXCR4表达水平有明显上升的趋势，差异有统计学意义（P<0.05）。
结论 CXCR4蛋白高表达与结肠癌的恶性程度及预后相关，提示CXCR4与结肠癌的发生发展存在相关性。
关键词：结肠癌，CXCR4，免疫组化
[Abstract] Objective To analyze chemokine receptor 4 (chemokine receptor4, CXCR4) expression in colon cancer its relationship with clinicopathological features and prognosis.
Methods The expressions of CXCR4 protein were probed by immunohistochemical staining in 98 specimens of colon cancer and 23 specimens of paracancerous from second Affiliated Hospital of Nantong University and its relationship with clinicopathological features and prognosis was then analyzed．Results The positive rate of CXCR4 expression in the colon cancer group (72.0%, 36/50) was significantly higher than in paracancerous normal tissue group (10%, 1/10) (P <0.05). The CXCR4 expression in colon cancer patients with different gender, age, tumor location, tumor size, histological was no significant difference (P> 0.05). However，the significant upregulation of CXCR4 expression in invasion of colon serosa group，lymph node metastasis group, and high TNM stage groups with respect to others were found(P <0.05). Conclusions The protein expression of CXCR4 was up-regulated in the colon cancer and is related to colon cancer malignancy and prognosis, which indicate CXCR4 exert its function on the development of the colon cancer.
[Key words] Colon cancer; CXCR4; Immunohistochemistry
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