目的：探讨结直肠癌组织中ADAM-9的表达及临床病理因素之间关系；并对病人进行术后随访，探讨ADAM-9表达与结直肠癌患者预后的关系。方法：应用免疫组化（IHC）检测不同临床分期的结直肠癌组织（72例）中ADAM-9的表达情况，并于正常组织对比。对术后所有病例患者进行电话随访，通过统计学计算分析探讨ADAM-9与结直肠癌患者预后的关系。结果： IHC结果显示，ADAM-9在正常组织中为阴性表达，在癌组织中为高表达，结直肠癌组中ADAM-9的阳性率为（69.44%，50/72）明显高于正常组织组（0%，0/10），结果具有统计学意义（P<0.05）。ADAM-9的表达与结直肠癌患者的性别、年龄、肿瘤大小、组织学类型均无统计学意义（P>0.05），与肿瘤侵犯深度、淋巴结转移，TNM分期，有统计学意义（P<0.05）。Kaplan-Meier生存分析显示，ADAM-9表达阳性表达的结肠腺癌患者术后生存期明显低于阴性表达者，差异有统计学意义（P<0.05）。结论：ADAM-9的表达情况与肿瘤TNM临床分期和浸润深度、有无淋巴结转移呈正相关，与结肠癌术后患者的复发时间呈负相关。提示ADAM-9可作为预测结肠癌生存期的指标，用于术后复发风险的评估。

Objective To study the expression of ADAM-9 in human’s colorectal cancer tissues and the relationship between ADAM-9 and the clinical pathological factors of colorectal cancer. Follow up the recurrence of patients with colorectal cancer after operation, research ADAM-9’s expression and the prognosis of colorectal cancer. Methods Colorectal cancer tissues (80 cases) and normal colorectal tissues (10 cases) were obtained from patients. ADAM-9 protein was measured by immunohistochemistry (Envision method), And in all cases the patients were followed up by telephone, by statistical calculation and analysis the relations between ADAM-9 and the recurrence of colorectal cancer. Results ADAM-9 mRNA were overexpresssed in cancer tissues and lowexpressed in normal tissues .The expression of ADAM-9 in colorectal carcinoma is associated with tumor TNM clinical stage and depth of invasion, lymph node metastasis which may be associated with the prognosis of gastric cancer（P<0.05）. The expression of ADAM-9 in patients with patients' gender, age, tumor location, tumor size, histological type had no statistical significance (P>0.05).The survival time of patients with ADAM-9 positive was significantly lower than that of patients with negative expression （P<0.05）. Conclusions ADAM-9 was overexpressed in colorectal cancer tissues and was related with tumor TNM clinical stage and depth of invasion, lymph node metastasis and the prognosis of colorectal cancer. ADAM-9 may be a prognostic indicator of colorectal cancer to assess recurrence risk in patients with colorectal cancer. Keywords: colorectal cancer，ADAM-9，prognosis