目的 探讨内镜超声引导下细针穿刺抽吸术(EUS-FNA)对上消化道壁隆起性病变的诊断准确性及其临床应用价值。方法 对2011年11月-2013年12月间35例患者行超声内镜检查及超声内镜引导下的细针穿刺检查，对比细胞学和（或）病理学检查与术后病理结果及随访结果。结果 共35例患者成功进行了EUS-FNA，穿刺成功率100％。其中病灶位于食管4例（11.43%，4/35），胃26例（74.29%，26/35），十二指肠球部5例（14.28%，5/35）。29例患者细胞学检查结果阳性，阳性率为82.85%（29/35）。15例患者获得组织碎片或组织细条行病理学检查，组织获得率为42.86%（15/35），其中10例病理学检查结果阳性，阳性率为60.66%（10/15）。与术后病理结果及长期随访结果对照，EUS-FNA后细胞学和（或）病理学检查的诊断准确率为85.71%（30/35）。结论 在上消化道及周围实质性占位病变中，EUS-FNA是一项安全、有效、准确的诊断及鉴别诊断方法。

Objective To evaluate the accuracy and clinical application of endoscopic ultrasound guided fine needle aspiration(EUS-FNA) in diagnosis of occupying lesions in upper digestive tract and its peripheral areas．Methods Forty-six patients underwent endoscopic ultrasonagraphy and EUS-FNA between November 2011 and December 2013．The result of cytology and／or pathology was compared with that of surgical finding and follow-up study．Results EUS-FNA was successfully performed on 35patients，with a success rate of100%． The35patients with lesions in oesophagus (4 cases), stomach(26 cases), duodenalbulb(5 cases). Among them,the lesions in 29 patients (82.85%) were cytologically confirme．The lesions in10 out of15 patients (60.66%) were pathologically confirmed．Compared with the results of pathology and long-term followe-up study，the overall diagnostic accuracy of EUS-FNA in diagnosis of lesions in upper digestive tract and its peripheral areas was 85.71%(30/35). There were no complications during the procedures. Conclusion EUS-FNA is a safe, effective and accurate method for diagnosis of occupying lesions in upper digestive tract and its peripheral areas.