摘要 目的 分析磨玻璃密度（ground glass opacity, GGO）肺腺癌CT特征与脏层胸膜浸润的关系。 方法 选择2013年9月至2014年10月于我院接受手术治疗且术后病理证实为腺癌的740例肺部GGO，其中脏层胸膜浸润组84例，无浸润组656例，分析其与CT特征之间的关系。 结果 患者年龄、GGO类型、GGO最大直径、实性成分直径、实性成分比例、距胸膜最小距离、胸膜凹陷征、边缘、形状均与脏层胸膜浸润情况有关，多因素logistic回归分析显示GGO最大直径>12mm、实性成分直径>5mm、距胸膜最小距离<6mm、胸膜凹陷征、粗糙边缘是脏层胸膜浸润的危险因素（OR=3.23, 4.41, 3.58, 2.21, 2.65），联合以上五个因素判别浸润情况的曲线下面积（area under curve, AUC）达到0.861。 结论 术前CT特征用于判别表现为GGO的肺腺癌的脏层胸膜浸润情况有重要价值。

Abstract Objective To analyze the correlation between CT characteristics and visceral pleural invasion (VPI) in lung adenocarcinoma presented with ground glass opacity (GGO). Methods 740 GGOs diagnosed with adenocarcinoma were selected, including 84 lesions with VPI. Results Age, GGO types (pure or part solid), the largest whole diameter, the largest diameter of consolidation, the proportion of consolidation, the distance from lesions to pleura, pleural retraction, margins (smooth or nonsmooth) and shape (round/oval or irregular) were significantly associated with VPI. Multivariate logistic regression analysis showed the largest whole diameter >12mm, the largest diameter of consolidation >5mm, the distance from lesions to pleura <6mm, pleural retraction, nonsmooth margin were risk factors of VPI (OR=3.23, 4.41, 3.58, 2.21, 2.65). The area under the receiver operating curve of multivariate analysis model was 0.861. Conclusion Preoperative CT was useful in evaluating VPI for pulmonary GGO diagnosed with adenocarcinoma.