目的 探讨血管生成拟态（vasculogenic mimicry, VM）与大肠癌肝转移相关性。方法 免疫组织化学染色观察115例大肠癌患者癌组织中VM的生成情况，其中伴有肝转移患者25例，无肝转移患者90例。调查回访手术后2年中这115例大肠癌患者的复发和肝转移状况。结果 手术前伴有肝转移的患者中64.0%的患者VM为阳性，而无肝转移组仅有26.7%为VM阳性。无肝转移的患者手术后2年内复发和肝转移的发生与VM的生成相关性具有统计学意义，P值分别为0.0003和小于0.0001。结论 VM与大肠癌的复发及肝转移成正相关。
Objective Explore the relationship between vasculogenic mimicry and liver metastasis of colorectal cancer. Methods Analysis of vasculogenic mimicry formation in 115 colorectal carcinoma patients by immunohistochemical staining. Among the colorectal carcinoma patients, 25 were with liver metastases and 90 without liver metastases. Monitor cancer recurrence and liver metastases of these 115 patients by surveying for 2 years. Restults Among patients with liver metastases, 64.0% were VM positive. While only 26.7% were VM positive among patients without liver metastases. Recurrence and liver metastases of patients without liver metastases before operation were statistically significant with VM existence with the P values of 0.0003 and less than 0.0001, respectively. Conclusion VM was positively associated with recurrence and liver metastases of colorectal cancer.
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