摘要：目的 探讨具有“自发退变”特征—广泛出血坏死囊性变的胸腺瘤的临床病理学特点，以提高对具有此类少见特征的胸腺瘤的认识。方法 对2例具有广泛出血、坏死、囊性变特征的胸腺瘤进行临床病理学分析及免疫组织化学染色，并结合文献讨论。结果 这两例胸腺瘤均出现广泛的出血、坏死及囊性变，例1，女，61岁，诊断B2型胸腺瘤部分侵犯胸膜、Masaoka分期 III期，随访28个月，肿瘤无复发和转移。例2，男，65岁，诊断B2型胸腺瘤，Masaoka分期I期，随访6个月肿瘤无复发和转移。结论 伴有广泛凝固性坏死、出血、囊性变的胸腺瘤可能具有惰性的生物学行为，但需要积累更多的临床资料和延长随访时间来评价这类患者的预后。

Abstract: Purpose To investigate clinicopathological features of thymoma with spontaneous regression including extensive hemorrhage, necrosis and cystic changes, so as to deepen the understanding of this entity type of thymoma. Methods clinicopathological features of two cases of thymomas with extensive hemorrhage, necrosis and cystic changes were analyzed and discussed combing related literature. Results The prognosis of two cases were both good with follow-up time 28 months and 6 months respectively, one case is a female patient, 61 years old with B2 thymoma , Masaoka stage III, and the other case is a male patient, 65 years old with B2 thymoma, Masaoka stage I. Conclusions This entity of thymoma with extensive hemorrhage, necrosis and cystic changes may have inert biological behavior, but the more clinic data and prolonging follow-up time were needed to evaluate the prognosis of these patients.