目的 探讨肝硬化患者上消化道出血与幽门螺杆菌(H.pylori)感染关系。方法 回顾性分析2013年1月—2017年12月收治的肝硬化患者342例,对本组患者幽门螺杆菌感染、食管胃底静脉曲张、消化性溃疡情况进行分析。结果 H.pylori阳性组上消化道出血发生率(43.93%)明显高于H.pylori阴性组(34.72%),两组比较差异有统计学意义(P<0.05);H.pylori阳性组消化性溃疡发生率(54.02%)明显高于H.pylori阴性组(37.5%),两组比较差异有统计学意义(P<0.05)。结论 H.pylori感染和肝硬化上消化道出血相关,根除H.pylori有可能降低肝硬化上消化道出血。

Objective To investigate the relationship between upper gastrointestinal bleeding and Helicobacter pylori (H.pylori) infection in patients with liver cirrhosis.Methods Clinical data of 342 cases of liver cirrhosis from January 2013 to December 2017 were retrospectively analyzed.H.pylori infection, esophageal varices in the fundus of the stomach, and peptic ulcer were analyzed.Results The rate of upper gastrointestinal bleeding in the H.pylori positive group (43.93%) was significantly higher than that in the H.pylori negative group (34.72%) (P<0.05).The rate of peptic ulcer in the H.pylori positive group (54.02%) was significantly higher than that in the H.pylori negative group (37.5%) (P<0.05).Conclusion H.pylori infection and upper gastrointestinal bleeding are correlated in the patients of liver cirrhosis.Eradication of H.pylori infection may reduce upper gastrointestinal bleeding in patients with liver cirrhosis.