目的 观察加速康复外科治疗对结直肠癌患者营养状况及免疫功能的影响。方法 将2016年3月—2018年3月64例结直肠癌患者随机分为对照组(33例)与观察组(31例),观察组予以加速康复外科理念治疗,对照组施行常规治疗。术前,术后1 d、3 d、7 d分别检测两组患者血清白蛋白(ALB)、前白蛋白(PA)、铁蛋白(SF)等营养指标和免疫球蛋白IgA、IgG、IgM等体液免疫功能指标。结果 观察组PA除术后1 d明显低于术前水平(P<0.05)外,术后3 d、7 d均与术前水平比较无差异; 对照组术后3 d的PA、ALB、SF与术前比较具显著差异(P<0.05),术后7 d恢复至术前水平,观察组PA、ALB、SF变化幅度明显小于对照组(P<0.05)。两组术后免疫功能指标均发生变化,术后3 d明显低于术前水平(P<0.05),术后7 d恢复至术前水平,观察组IgA、IgG、IgM变化幅度亦小于对照组(P<0.05)。结论 加速康复外科治疗可改善结直肠癌患者营养状况和免疫功能。

Objective To observe the changes of nutrition and immune function indices of patients with colorectal cancer using enhanced recovery after surgery.Methods A total of 64 patients with colorectal cancer admitted from March 2016 to March 2018 were divided into control group (n=33) and observation group (n=31).The patients in the observation group received enhanced recovery after surgery; the patients in the control group received conventional treatment.The nutrition indices (ALB,PA,and SF) and immune indices (IgA,IgG,and IgM) of the two groups before surgery and 1 day,3 days,and 7 days after surgery were detected.Results In the observation group,except for a lower level 1 day after surgery (P<0.05),no differences in PA level were observed between 3 days or 7 days after surgery and before surgery.In the control group,the PA,ALB,and SF 3 days after surgery had statistical differences compared with before surgery(P<0.05) and returned to the preoperative level 7 days after surgery.The changes of ALB,PA,and SF levels of the observation group were smaller than those of the control group (P<0.05).The postoperative immune function indices of both groups changed,and the levels 3 days after surgery were lower than before (P<0.05),and returned to the preoperative level 7 days after surgery.The changes of IgA,IgG,and IgM levels of the observation group were smaller than those of the control group as well (P<0.05).Conclusion Enhanced recovery after surgery could relieve the nutritional status and immune function of patients with colorectal cancer.