结肠癌患者循环肿瘤细胞与临床病理分期的相关性研究

葛海燕; 张振宇; 付正伟; 纪昉; 高玮; 顾跃明; 王志强; 马伟伟

doi:10.3969/j.issn.2095-378X.2018.01.001

外科研究与新技术（中英文） >

2018 , Vol. 7 >Issue 1: 1 - 3

DOI: https://doi.org/10.3969/j.issn.2095-378X.2018.01.001

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结肠癌患者循环肿瘤细胞与临床病理分期的相关性研究

葛海燕 ,
张振宇 ,
付正伟 ,
纪昉 ,
高玮 ,
顾跃明 ,
王志强 ,
马伟伟

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1.浙江省平湖市第二人民医院外科,平湖 314201;
2.同济大学附属上海市东方医院胃肠肛肠外科,上海 200120

葛海燕(1958—),男,硕士,主任医师,从事胃肠道肿瘤的外科治疗;电子信箱:gesurgery@163.com

收稿日期: 2017-12-18

网络出版日期: 2019-12-12

基金资助

浙江省嘉兴市科技局资助项目(2015AY23071);上海市科委课题(16411970800);上海市卫计委课题(20134194)

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Relationship between circulating tumor cells and clinical pathologic stages in patients with colon cancer

GE Haiyan ,
ZHANG Zhenyu ,
FU Zhengwei ,
JI Fang ,
GAO Wei ,
GU Yueming ,
WANG Zhiqiang ,
MA Weiwei

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1.Department of General Surgery, Pinghu Second People’s Hospital, Pinghu 314201, China;
2.Department of Gastrointestinal Surgery, East HospitalAffiliated to Tongji University, Shanghai 200120, China

Received date: 2017-12-18

Online published: 2019-12-12

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摘要

目的了解结肠癌患者循环肿瘤细胞(CTCs)与临床病理分期之间的相关性。方法应用Cell Search 技术检测未经治疗的结肠癌患者外周血中CTCs数量,并观察与临床病理分期的相关性。结果在32例首诊为结肠癌患者中,术前外周血检出CTCs阳性13例,阳性率40.6%;CTCs阳性率与患者年龄、性别、肿瘤大小、神经侵犯无关;与结肠癌浸润深度、TNM分期、脉管侵犯相关(P<0.05),TNM分期高(Ⅲ+Ⅳ)患者的CTCs阳性率显著高于TNM分期低(Ⅰ+Ⅱ)患者(P<0.05)。结论结肠癌患者外周血中检测到CTCs,提示其临床病理分期也可能较差。

关键词： 结肠癌; 循环肿瘤细胞; 肿瘤病理分期

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葛海燕 , 张振宇 , 付正伟 , 纪昉 , 高玮 , 顾跃明 , 王志强 , 马伟伟 . 结肠癌患者循环肿瘤细胞与临床病理分期的相关性研究[J]. 外科研究与新技术（中英文）, 2018 , 7(1) : 1 -3 . DOI: 10.3969/j.issn.2095-378X.2018.01.001

Abstract

Objective To understand the relationship between circulating tumor cells (CTCs) and clinical pathologic stages in patients with colon cancer.Methods CTCs counts in peripheral blood of untreated patients with colon cancer were detected by CellSearch technique.The relationship between CTCs and clinical pathologic stages of colon cancer was analyzed.Results CTCs in peripheral blood were detected in 40.6% (13/32) untreated cases of colon cancer.Significant relationships of positive CTCs were identified with colon cancer infiltration, TNM stage, and blood vessel infiltration (P<0.05), but not with age, sex, tumor size, and nerve infiltration.The Ⅲ+Ⅳ TNM stage patients had a much higher positive rate of CTCs than the Ⅰ+Ⅱ TNM stage patients (P<0.05).Conclusion CTCs can be detected in the peripheral blood of colon cancer patients, indicating higher clinicopathological stages.

Key words： Colon cancer; Circulating tumor cell; Tumor pathologic stage

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