目的 探讨S100A7 在肝内胆管癌组织中的表达及其临床意义。方法 收集东方肝胆外科医院2018年1月—2020年1月经病理证实的30例肝内胆管癌标本,应用免疫组化、免疫印迹、PCR方法检测S100A7在肝内胆管癌细胞中的表达水平。结果 肝内胆管癌S100A7表达阳性百分比明显高于癌旁组织（50%对10%, P<0.05）。S100A7表达与肿瘤浸润深度、淋巴结转移、TNM分期呈显著正相关（P<0.05）,但与患者患者性别、年龄、淋巴管侵犯、肿瘤分化程度、远处转移无关。结论 肝内胆管癌S100A7高表达,可能有助于预测肝内胆管癌患者的预后。
Objective To observe the expression of S100A7 in intrahepatic cholangiocarcinoma （ICC） and its clinical significance. Methods Tissue specimens from 30 cases of pathologically proven ICC were collected in the Eastern Hepatobiliary Surgery Hospital from January 2018 to January 2020. The expression of S100A7 in ICC tissue was analyzed by immunohistochemistry, Western blotting and PCR. Results The S100A7 level expressed in ICC tissue was significantly higher than that in para-carcinoma （50% vs. 10%, P<0.05）.The expression of S100A7 was correlated with the depth of tumor invasion, lymph node metastasis and TNM stage （all P<0.05）, but not correlated with the patient's sex, age, lymphatic invasion, tumor differentiation and distant metastasis. Conclusion S100A7 is overexpressesd in ICC, which is helpful to evaluate the prognosis of patients with ICC.
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