目的 探讨急性坏疽性胆囊炎的诊断方法及腹腔镜治疗的效果。方法 收集2017年1月—2019年12月收治的39例坏疽性胆囊炎患者的临床资料,对其诊断方法、手术方式及诊疗结果进行回顾分析。结果 共实施腹腔镜胆囊切除术4 365例,其中确诊为坏疽性胆囊炎患者共39例(0.9%)。39例坏疽性胆囊炎中31例顺利完成腹腔镜胆囊切除术,7例因胆囊三角区暴露不佳而中转行开腹手术,1例高龄患者合并心肺功能障碍直接行开腹胆囊切除术。结论 坏疽性胆囊炎术前诊断困难,B超、上腹部CT等检查均可作为提高术前诊断率的有效方法。腹腔镜可以安全处理大多数坏疽性胆囊炎,对于小部分粘连严重、不能耐受腹腔镜胆囊切除术的患者应及时行开腹手术处理。
Objective To investigate the diagnosis of acute gangrenous cholecystitis and the effect of laparoscopy. Methods The clinical data of 39 cases of gangrenous cholecystitis treated from January 2017 to December 2019 were collected, and their diagnostic methods, surgical methods, and diagnosis and treatment results were analyzed. Results A total of 4365 cases of laparoscopic cholecystectomy (LC) were performed, of which 39 cases were diagnosed with gangrenous cholecystitis, accounting for 0.9% of total LC. Thirty-one of the 39 cases of gangrenous cholecystitis successfully underwent LC, 7 cases were converted to open cholecystectomy (OC) due to obscure anatomy at the triangle of the gallbladder, and 1 elderly patient with cardiopulmonary dysfunction underwent OC. Conclusion The diagnosis of gangrenous cholecystitis is difficult before operation. Ultrasound and upper abdominal CT examinations are effective methods to improve preoperative diagnosis rate. LC can safely treat most gangrenous cholecystitis, and in-time OC is suggested in case of severe adhesions and LC intolerance.
[1] Bourikian S, Anand RJ, Aboutanos M, et al.Risk factors for acute gangrenous cholecystitis inemergency general surgery patients[J]. Am J Surg, 2015,210(4):730-733.
[2] Ganapathi AM, Speicher PJ, Englum BR, et al.Gangrenous cholecystitis: a contemporary review[J]. J Surg Res, 2015,197(1):18.
[3] Alghamdi KA, Rizk HA, Jamal WH, et al.Risk factors of gangrenous cholecystitis in general surgery patient admitted for cholecystectomy in King Abdul-Aziz University Hospital(KAUH), Saudi Arabia[J]. Mater Sociomed,2019,31(4):286-289.
[4] Aydin C, Altaca G, Berber I, et al.Prognostic parameters for the prediction of acute gangrenous cholecystitis[J]. J Hepatobiliary Pancreat Surg, 2006,13(2):155-159.
[5] 张志强. 坏疽性胆囊炎发生的危险因素分析[J]. 肝胆胰外科杂志,2016,28(4):278-281.
[6] Wu B, Buddensickt J, Ferdosi H, et al.Predicting gangrenous cholecystitis[J]. HPB (Oxford), 2014,16(9):801-806.
[7] Yokoe M,Hata J,Takada T,et,al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos)[J]. J Hepatobiliary Pancreat Sci,2018,25(1):41-54.
[8] Mok KW, Reddy R, Wood F, et al.Is C-reactive protein a useful adjunct in selecting patients for emergency cholecystectomy by predicting severe/gangrenous cholecystitis?[J]. Int J Surg, 2014,12(7),649-653.
[9] Yoon SL, Kwang BC, Kyung SP, et,al. Procalcitonin as a decision-supporting marker of urgent biliary decompression in acute cholangitis[J]. Dig Dis Sci,2018,63(9):2474-2479.
[10] Raffee L, Kuleib S, Oteir A, et al.Utility of leucocytes, inflammatory markers and pancreatic enzymes as indicators of gangrenous cholecystitis[J]. Postgrad Med J,2020,96(1133):134-138.
[11] Simeone J, Fbrink JA, Mueller PR, et al.The sonographic diagnosis of acute gangrenous cholecystitis: importance of the murphy sign[J]. AJR Am J Roentgenol,1989,152(2):289-290.
[12] Bader HS, Hamza AS, Muhammad AS, et al.Predictive factors for gangrene complication in acute calculous cholecystitis[J]. J Hepatobiliary Pancreat Surg, 2019,23(3):228-233.
[13] Seda B, Rahul JA, Michel A, et al.Risk factors for acute gangrenous cholecystitis in emergency general surgery patients[J]. Am J Surg Pathol,2015,210(4):730-733.
[14] Lee NW, Collins J, Britt R, et a1.Evaluation of preoperative risk factors for converting laparoscopic to open cholecystectomy[J]. Am Surg,2012,8(78):831-833.
[15] 冯一浮, 莫经刚, 陈建辉. 急性胆囊炎腹腔镜胆囊切除术中转开腹相关风险因素的分析[J]. 中国普通外科杂志, 2016, 25(2):286-290.
[16] Ryousuke K, Jiro H, Noriaki M, et al.Contrast-enhanced ultrasonography with sonazoid for diagnosis of gangrenous cholecystitis[J]. J Med Ultrason,2016,43(2):193-199.
[17] 陆殿元,周柱玉,蔡建荣,等.急性坏疽性胆囊炎超声声像图分析[J].临床急诊杂志,2014,15(4):192-193.
[18] Oppenheimer DC, Rubens DJ.Sonography of acute cholecystitis and its mimics[J]. Radiol Clin N Am, 2019,57(3):1-14.
[19] 赵黎明,宋彬,吴苾,等.急性胆囊炎的CT和MRI诊断价值[J].中国普外基础与临床杂志,2008,15(9):699-703.
[20] 刘松,胡道予,彭俊红.急性坏疽性胆囊炎的CT诊断价值[J].放射学实践,2019,34(5):530-534.
[21] Uemura S, Higuchi R, Yazawa T, et al.Impact of transient hepatic attenuation differences on computed tomography scans in the diagnosis of acute gangrenous cholecystitis[J]. J Hepatobiliary Pancreat Sci,2019,26(8):348-353.
[22] 杨如高,连立之,张佳文,等.开腹和腹腔镜胆囊切除术治疗老年急性坏疽性胆囊炎的临床分析[J].国际外科学杂志,2017,44(10):680-684.
[23] 李元君,陈治强.腹腔镜胆囊切除术治疗老年急性坏疽性胆囊炎54例报道[J].重庆医学,2012,41(19):1938-1939.
[24] 罗文,付文广.老年急性坏疽性胆囊炎行腹腔镜胆囊切除术体会与并发症预防[J].现代仪器与医疗,2018,24(4):116-118.
[25] 张晓征. 腹腔镜胆囊切除术应用于老年急性坏疽性胆囊炎临床价值探讨[J].肝胆外科杂志,2016,24(3):214-216.
[26] 游晓功,施宝民,荆丽艳,等.胆囊后三角应用解剖及其在腹腔镜胆囊切除术中的临床意义[J].中国实用外科杂志,2008,28(11):975-977.