目的 分析经自然腔道取标本手术（natural orifice specimen extraction surgery,NOSES）治疗左半结肠肿瘤的疗效及影响预后的危险因素。方法 回顾性分析2016年1月—2019年1月收治的60例左半结肠肿瘤患者相关资料,分为对照组（常规根治术）和观察组（NOSES术）,对比两组患者相关手术指标、并发症发生情况,并分析影响患者预后相关因素。结果 观察组手术时间较长（P<0.05）,术中出血量、术后肛门首次排气及住院时间优于对照组（P<0.05）,并发症明显少于对照组（10.0%对33.3%,P<0.05）。单因素结合logistic多因素分析显示,分化程度、肿瘤分期、肿瘤位置、术后化疗、淋巴结转移为影响左半结肠癌患者预后的独立因素（P<0.05）。结论 NOSES术治疗左半结肠癌疗效较好,并发症较少;但同时应注意肿瘤分期、分化程度、术后化疗及淋巴结转移情况,以提升整体疗效。

Objective To investigate the curative effect of natural orifice specimen extraction surgery （NOSES） on left colon cancer and the risk factors affecting prognosis. Methods Sixty patients with left colon cancer in our hospital from January 2016 to January 2019 were enrolled in the retrospective analysis and divided into an observation group （NOSES） and a control group （conventional radical operation）. Relevant operation indices and complications between the two groups were compared, and the factors affecting prognosis were analyzed. Results The observation group showed longer operation time as well as less intraoperative blood loss, postoperative anal exsufflation time, and hospital stay than the control group did （P<0.05）; the incidence rate of complications in the observation group was lower than that in the control group （10.0% vs. 33.3%, P<0.05）. The results of single factor analysis and multiple logistic regression model showed that tumor differentiation degree, tumor stage, tumor location, postoperative chemotherapy, and lymph node metastasis were the independent factors affecting the prognosis of patients with left colon cancer （P<0.05）. Conclusion NOSES is an effective surgery for left colon cancer, producing less complications. Special attention should be paid to tumor differentiation degree, tumor stage, postoperative chemotherapy, and lymph node metastasis, so as to improve the overall curative effect.