目的 分析人工流产（人流）手术前阴道予以米索前列醇对宫颈的软化效果。方法 选取2020年1月—2021年3月开展人流手术的58例患者为研究对象,依据随机数表法划分成对照组（常规开展人工流产,术前未开展宫颈软化治疗）和观察组（开展人工流产前阴道使用米索前列醇）各29例,统计并比较两组术中失血量、手术时间、宫颈扩张直径、扩宫时间、宫缩幅度、麻醉药用量、宫颈扩张度、术前术后疼痛评分和人流综合征等副反应出现情况。结果 观察组的术中失血量及麻醉药用量少于对照组,手术及扩宫时间短于对照组,同时宫颈扩张直径长于对照组,宫缩幅度高于对照组（P<0.05）。观察组的宫颈扩张有效率为100.00％比对照组31.03％更高（P<0.05）。术前,观察组疼痛评分高于对照组（P>0.05）;术后1 h,观察组疼痛评分低于对照组（P<0.05）。两组患者均顺利结束手术,其中观察组1例产生人流综合征,发生率为3.45％（1/29）,对照组8例产生人流综合征,发生率为27.59％（8/29）,均经治疗后好转,两组未产生人流不全和子宫穿孔等一系列严重副反应与并发症,观察组的人流综合征出现少于对照组（P<0.05）。结论 人流手术前阴道予以米索前列醇能对宫颈起到良好软化效果,减少患者术中的失血量及麻醉药用量,减轻其术后疼痛感,减少人流综合征等副反应出现。

Objective To analyze the effect of preoperative vaginal misoprostol on cervical softening. Methods A total of 58 patients undergoing induced abortion from January 2020 to January 2021 in our hospital were chosen as study subjects, and according to random number table, divided into a control group （29 cases, without preoperative cervical softening） and an observation group （29 cases, with preoperative cervical softening using vaginal misoprostol）. Comparisons were performed in intraoperative bleeding volume, operation time, cervical dilation diameter, dilation time, uterine contraction degree, anesthetic drug dosage, cervical dilation degree, pain scores before and after surgery, and side effects such as abortion syndromes. Results The intraoperative bleeding volume and the anesthetic drug dosage in the observation group were lower than those in the control group; the operation time and the dilation time were shorter; the cervical dilation diameter was larger; the uterine contraction degree was higher （P<0.05）. The effective cervical dilation rate in the observation group （100.00％） was higher than that in the control group （31.03％） （P<0.05）. Before surgery, the pain score in the observation group was higher than that in the control group （P>0.05）; whereas at postoperative 1 h, the pain score was lower （P<0.05）. Both groups completed the surgery successfully. The observation group had one case of abortion syndrome （3.45％, 1/29）, the control group had eight cases of abortion syndrome（27.59％, 8/29）, and all the cases of abortion syndrome improved after treatment. No serious adverse side effects and complications occurred, such as incomplete abortion and uterine perforation. The cose of abortion syndromes in the observation group was lower than that in the control group （P<0.05）. Conclusion Preoperative vaginal misoprostol application can reduce intraoperative bleeding volume, anesthetic drug dosage, pain degree after surgery, and abortion syndromes.