目的 观察精准肝切除治疗原发性肝癌(PLC)的临床疗效。方法 选取2019年6月—2021年6月莆田学院附属医院肝胆外科收治的104例PLC患者,随机分为观察组和对照组,对照组采取传统肝切除术,观察组采取精准肝切除术;对照两组手术相关指标、治疗前后肝功能及手术并发症。结果 观察组手术出血量、术后住院天数少于对照组(P<0.05);两组术前肝功能指标无差异,术后主要肝功能指标较术前上升,但观察组上升值低于对照组(P<0.05);观察组术后胆漏、腹水等并发症发生率低于对照组(P<0.05)。结论 精准肝切除治疗PLC显著减少术中出血、促进术后恢复,减轻肝功能损害,并发症较少,疗效显著。
Objective To observe the clinical efficacy of precision hepatectomy for primary liver cancer (PLC). Methods A total of 104 PLC patients admitted to the Department of Hepatobiliary Surgery, Affiliated Hospital of Putian University from June 2019 to June 2021 were randomly divided into an observation group and a control group. The control group received traditional liver resection, while the observation group received precision hepatectomy. Operation related indexes, liver function before and after treatment, and surgical complications in the two groups were compared. Results The amount of intraoperative bleeding and postoperative hospitalization days in the observation group were less than those in the control group (P<0.05). There was no significant difference in liver function indexes between the two groups before operation (P>0.05), and the values of the main liver function indexes in the two groups after operation were higher than those before operation, but the increment values in the observation group were lower than those in the control group (P<0.05). The incidence rates of postoperative biliary leakage, ascites, and other complications in the observation group were lower than those in the control group (P<0.05). Conclusion Precision hepatectomy for PLC can significantly reduce intraoperative bleeding, promote postoperative recovery, reduce the damage of liver function, and has fewer complications, showing significant efficacy.
[1] 刘文斌, 荚卫东. 《原发性肝癌诊疗规范(2019年版)》解读[J]. 肝胆外科杂志, 2020, 28(6): 468-472.
[2] 郭昊苏, 刘宏, 李凯, 等. 肝切除在精准外科理念下治疗原发性肝癌近期疗效的荟萃分析[J]. 临床与病理杂志, 2021, 41(2): 395-409.
[3] 洪峰华, 黄大海, 叶彬, 等. 3D可视化联合3D打印在肝癌大部分肝切除术中的应用[J].中国医学物理学杂志, 2020, 37(7): 883-889.
[4] 黎涛, 石承先, 王雪梅. 肝细胞性肝癌手术治疗的疗效及影响因素观察[J]. 临床医药文献电子杂志, 2020, 7(30): 53.
[5] 简学仲, 谢曦, 杨光福, 等. 腹腔镜肝门解剖性手术治疗肝细胞性肝癌的短期疗效观察及对患者免疫应答及肝功能的影响[J]. 中国老年学杂志, 2020, 40(1): 46-49.