目的 研究精囊镜对精囊腺梗阻引发的血精症患者的疗效及应用安全性并予以分析,目的 在于为精囊腺梗阻引发的血精症患者寻求一种积极有效的治疗方式。方法 选取2017年4月—2022年6月成武县人民医院收治的82例精囊腺梗阻引发的血精症患者纳入研究。按照电脑随机数字表法分成手术组和保守组,每组各41例。保守组实施综合保守治疗,手术组则实施经尿道精囊镜手术治疗。比较两组临床疗效,治疗前后性功能变化情况,治疗前后精液红细胞、白细胞含量,并发症发生情况。结果 手术组治疗总有效率高于保守组(P<0.05)。治疗后手术组及保守组勃起功能评分(IIEF-5)与射精功能评分(CIPE)相较于治疗前均明显提高,且手术组高于保守组(均P<0.05)。治疗后手术组及保守组的精液红细胞、白细胞计数均少于治疗前,且手术组少于保守组(均P<0.05)。手术组与保守组在尿道狭窄、尿失禁及感染发生率方面对比均不明显(均P>0.05)。结论 精囊镜的应用可显著提高精囊腺梗阻引发的血精症患者临床疗效,提高患者的性功能,同时减少精液红细胞、白细胞计数,术后并发症发生风险较小,安全性较佳。
Objective To study the efficacy and safety of seminal vesiculoscopy in patients with hematospermia induced by seminal vesicle gland obstruction, and to find a positive and effective treatment for the disease. Methods A total of 82 patients with hematospermia induced by seminal vesicle gland obstruction admitted to Chengwu County People's Hospital from April 2017 to June 2022 were included in the study. According to the method of computer random number table, the patients were divided into an operation group and a conservative group, 41 cases in each group. The conservative group received comprehensive conservative treatment, while the operation group received transurethral seminal vesiculoscopy. The clinical efficacy, sexual function changes, red blood cell (RBC) and white blood cell (WBC) contents in semen before and after treatment, and complications were compared between the two groups. Results The total effective rate of the operation group was higher than that of the conservative group (P<0.05). The International Index of Erectile Function-5 (IIEF-5) and Chinese Index of Premature Ejaculation (CIPE) scores of the operation group and the conservative group after treatment were significantly higher than those before treatment, and the scores of the operation group were higher than those of the conservative group (P<0.05). After treatment,the counts of RBC and WBC in the operation group and the conservative group were all lower than those before treatment, and the counts in the operation group were lower than those in the conservative group (P<0.05). There were no significant differences in urethral stricture, urinary incontinence, and infection rate between the operation group and the conservative group (P>0.05). Conclusion The application of seminal vesiculoscopy can significantly improve the clinical efficacy of hematospermia patients induced by seminal vesicle gland obstruction, improve sexual function, and reduce the counts of semen RBC and WBC, with a small postoperative complication risk and high safety.
[1] Yusuf S,Joseph P,Rangarajan S,et al.Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study[J].Lancet,2020,395(10226):795-808.
[2] Choi YB,Lee JW,Sung KW,et al.Impact of day 14 peripheral blood chimerism after allogeneic hematopoietic stem cell bone transplantation on the treatment outcome of non-malignant disease[J].J Korean Med Sci,2019,34(6):46-47.
[3] 邵继春,曾治军,王兴,等.射精管开口的分布规律及精囊镜进镜方式的初步研究[J].中华男科学杂志,2018,24(8):686-689.
[4] 吴科荣,罗爱平,殷玮琪,等.可视穿刺经皮肾镜用于精囊镜检查的可行性和安全性[J].中华泌尿外科杂志,2018,39(11):852-855.
[5] 黄灶明,李彦锋,张勇,等.34例尿道血管瘤临床特征及内镜诊治效果分析[J].第三军医大学学报,2019,41(20):1995-1999.
[6] 於佶,陈智勇,朱湘生,等.输尿管软镜在精囊疾病诊疗中的体会[J].中国医药导刊,2019,21(9):567-569.
[7] 张孝旭,陈小敏,孙大林,等.益肾降火汤加减治疗血精症40例临床观察[J].中国中医药科技,2019,26(2):225-226.
[8] 王飞,丁雪飞,徐嘉男,等.模板引导下经会阴的前列腺投影穿刺活检的并发症分析[J].中华医学杂志,2019,99(6):428-431.
[9] 朱勇,乐进,刘正建,等.盐酸舍曲林联合"三采嬉戏"疗法治疗原发性早泄的疗效观察[J].中华男科学杂志,2015,21(12):1116-1120.
[10] Shimizu R,Takeuchi M,Sakaida E,et al.Efficacy and safety of oral deferasirox treatment for transfusional iron overload in pure red cell aplasia patients after allogeneic stem cell transplantation[J].Ann Hematol,2019,98(7):1781-1783.
[11] Vijayaraghavan K,Szerlip HM,Ballantyne CM,et al.Icosapent ethyl reduces atherogenic markers in high-risk statin-treated patients with stage 3 chronic kidney disease and high triglycerides[J].Postgrad Med,2019,131(6):390-396.
[12] Amnuay K,Srisawat N,Wudhikarn K,et al.Factors associated with erythropoiesis-stimulating agent hyporesponsiveness anemia in chronic kidney disease patients[J].Hematol Rep,2019,11(3):8183-8184.
[13] 廖建,任正举,杨博,等.精囊镜技术治疗慢性精囊炎及血精症的疗效和安全性的Meta分析[J].中国临床研究,2018,31(5):609-614.
[14] 张彦桥,杨文增,林向阳,等.可视穿刺系统在血精患者临床诊治中的应用研究[J].中国内镜杂志,2017,23(11):97-100.
[15] 刘俊杰,陈仁富,王军起,等.经前列腺小囊精囊镜技术治疗血精疗效分析[J].徐州医学院学报,2017,37(8):542-543.
[16] 孙伟,张鑫,潘森,等.经尿道精囊镜技术在血精症患者诊治中的临床价值探析[J].中国性科学,2019,28(5):30-33.
[17] 蒋庆峰. 使用精囊镜技术对血精症患者进行诊疗的效果观察[J].当代医药论丛,2015,22(19):205-206.
[18] Zhu XB,Zhang XS,Zhang SL,et al.8.5/11.5F seminal vesicle mirror in the diagnosis and treatment of refractory blood fine application[J].J Chin Male Sci,2016,22(3):225-228.
[19] 杨时来,张鑫,杜伟,等.精囊镜治疗血精症36例的临床效果[J].重庆医学,2019,48(13):2309-2310.
[20] 向旭宇,黄珂,唐正严,等.精囊镜治疗难治性血精症的疗效分析[J].中华泌尿外科杂志,2018,39(3):205-208.