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荧光显像技术在泌尿外科的应用

  • 汤开然 ,
  • 韩邦旻
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  • 上海交通大学医学院附属第一人民医院泌尿中心,上海 200080
汤开然(1999—),女,博士研究生在读,从事临床泌尿外科工作

收稿日期: 2023-02-20

  网络出版日期: 2023-09-08

Application of fluorescence imaging in urology

  • TANG Kairan ,
  • HAN Bangmin
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  • Department of Urology, Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200080, China

Received date: 2023-02-20

  Online published: 2023-09-08

摘要

荧光引导手术(fluorescence-guided surgery, FGS)这一技术因其分辨率高、安全性好、可操作性强等优势,正被逐步应用于临床实践,尤其在泌尿外科领域。本文旨在阐述荧光显像技术的基本原理与发展历程,并讨论荧光示踪剂在泌尿外科领域应用的现状与发展前景。大力发展荧光引导手术的新兴技术,将有效提高外科手术切除病灶的准确性,同时减少术后不良反应,这一举措有利于促进精准医疗目标的实现。

本文引用格式

汤开然 , 韩邦旻 . 荧光显像技术在泌尿外科的应用[J]. 外科研究与新技术(中英文), 2023 , 12(2) : 81 -85 . DOI: 10.3969/j.issn.2095-378X.2023.02.001

Abstract

Fluorescence-guided surgery (FGS) is a technique that is applied in clinical practice progressively, especially in the field of urology, due to the advantages of high resolution, safety, and operability. The review is aimed at explaining the basic principles and development history of FGS, and discussing current status and prospects of fluorescent tracers in urology. The emerging technology of FGS can help effectively improve the accuracy of surgical resection of lesions while reduce postoperative adverse effects, contributing to achieving the goal of precision medicine.

参考文献

[1] van der Poel HG, Buckle T, Brouwer OR, et al. Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer[J]. Eur Urol, 2011, 60(4): 826-833.
[2] Alam IS, Steinberg I, Vermesh O, et al.Emerging intraoperative imaging modalities to improve surgical precision[J]. Mol Imaging Biol, 2018, 20(5): 705-715.
[3] Frangioni JV.Translating in vivo diagnostics into clinical reality[J]. Nat Biotechnol, 2006, 24(8): 909-913.
[4] de Boer E, Harlaar NJ, Taruttis A, et al. Optical innovations in surgery[J]. Br J Surg, 2015, 102(2): e56-72.
[5] Moore GE, Peyton WT, French LA, et al.The clinical use of fluorescein in neurosurgery; the localization of brain tumors[J]. J Neurosurg, 1948, 5(4): 392-398.
[6] Fox IJ, Wood EH.Indocyanine green: physical and physiologic properties[J]. Proc Staff Meet Mayo Clin, 1960, 7(35): 732-744.
[7] Manny TB, Patel M, Hemal AK.Fluorescence-enhanced robotic radical prostatectomy using real-time lymphangiography and tissue marking with percutaneous injection of unconjugated indocyanine green: the initial clinical experience in 50 patients[J]. Eur Urol, 2014, 65(6): 1162-1168.
[8] Wynne HA, Goudevenos J, Rawlins MD, et al.Hepatic drug clearance: the effect of age using indocyanine green as a model compound[J]. Br J Clin Pharmacol, 1990, 30(4): 634-637.
[9] Mieog JSD, Achterberg FB, Zlitni A, et al.Fundamentals and developments in fluorescence-guided cancer surgery[J]. Nat Rev Clin Oncol, 2022, 19(1): 9-22.
[10] van den Berg NS, van Leeuwen FW, van der Poel HG. Fluorescence guidance in urologic surgery[J]. Curr Opin Urol, 2012, 22(2): 109-120.
[11] Wachowska M, Muchowicz A, Firczuk M, et al.Aminolevulinic acid (ALA) as a prodrug in photodynamic therapy of cancer[J]. Molecules, 2011, 16(5): 4160-4164.
[12] Kriegmair M, Baumgartner R, Knuechel R, et al.Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid[J]. Urology, 1994, 44(6): 836-841.
[13] Mowatt G, N'Dow J, Vale L, et al. Photodynamic diagnosis of bladder cancer compared with white light cystoscopy: Systematic review and meta-analysis[J]. Int J Technol Assess Health Care, 2011, 27(1): 3-10.
[14] Inoue K, Fukuhara H, Shimamoto T, et al.Comparison between intravesical and oral administration of 5-aminolevulinic acid in the clinical benefit of photodynamic diagnosis for nonmuscle invasive bladder cancer[J]. Cancer, 2012, 118(4): 1062-1074.
[15] Hagimoto H, Makita N, Mine Y, et al.Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection[J]. BMC Urol, 2021, 21(1): 180.
[16] Denzinger S, Burger M, Walter B, et al.Clinically relevant reduction in risk of recurrence of superficial bladder cancer using 5-aminolevulinic acid-induced fluorescence diagnosis: 8-year results of prospective randomized study[J]. Urology, 2007, 69(4): 675-679.
[17] Fukuhara H, Yamamoto S, Karashima T, et al.Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy[J]. Int J Clin Oncol, 2021, 26(1): 18-25.
[18] Fukuhara H, Inoue K, Kurabayashi A, et al.Performance of 5-aminolevulinic-acid-based photodynamic diagnosis for radical prostatectomy[J]. BMC Urol, 2015, 15: 78.
[19] Mangano MS, De Gobbi A, Beniamin F, et al.Robot-assisted nerve-sparing radical prostatectomy using near-infrared fluorescence technology and indocyanine green: initial experience[J]. Urologia, 2018, 85(1): 29-31.
[20] Diana P, Buffi NM, Lughezzani G, et al.The role of intraoperative indocyanine green in robot-assisted partial nephrectomy: results from a large, multi-institutional series[J]. Eur Urol, 2020, 78(5): 743-749.
[21] Simone G, Tuderti G, Anceschi U, et al."Ride the green light": indocyanine green-marked off-clamp robotic partial nephrectomy for totally endophytic renal masses[J]. Eur Urol, 2019, 75(6): 1008-1014.
[22] Lerchenberger M, Gündogar U, Al Arabi N, et al.Indocyanine green fluorescence imaging during partial adrenalectomy[J]. Surg Endosc, 2020, 34(5): 2050-2055.
[23] Colvin J, Zaidi N, Berber E.The utility of indocyanine green fluorescence imaging during robotic adrenalectomy[J]. J Surg Oncol, 2016, 114(2): 153-156.
[24] Schlenker B, Gratzke C, Seitz M, et al.Fluorescence-guided laser therapy for penile carcinoma and precancerous lesions: long-term follow-up[J]. Urol Oncol, 2011, 29(6): 788-793.
[25] Yuen K, Miura T, Sakai I, et al.Intraoperative fluorescence imaging for detection of sentinel lymph nodes and lymphatic vessels during open prostatectomy using indocyanine green[J]. J Urol, 2015, 194(2): 371-377.
[26] 王喻, 梁伟聪, 孙卓伦, 等.荧光显像腹膜后淋巴结清扫在根治性前列腺切除术后淋巴结复发患者中的应用价值[J].中华泌尿外科杂志, 2021, 42(9): 666-669.
[27] Li TC, Wang Y, Xiao CT, et al.68Ga-PSMA ligand PET/CT integrating indocyanine green-guided salvage lymph node dissection for lymph node metastasis after radical prostatectomy[J]. Asian J Androl. 2022, 24(1): 97-101.
[28] 黄炳伟, 王杰, 张鹏, 等. 吲哚菁绿在复杂上尿路修复手术中的应用[J]. 北京大学学报(医学版), 2020, 52(4):651-656.
[29] Dirk Z, Ronald S, Michael H, et al.Photodynamic therapy by means of 5-ALA induced ppix in human prostate cancer- preliminary results[J]. Medical Laser Application, 2003, 91-95.
[30] Azzouzi AR, Barret E, Moore CM, et al.TOOKAD Soluble vascular-targeted photodynamic (VTP) therapy: determination of optimal treatment conditions and assessment of effects in patients with localised prostate cancer[J]. BJU Int, 2013, 112(6): 766-774.
[31] Azzouzi AR, Barret E, Bennet J, et al.TOOKAD® Soluble focal therapy: pooled analysis of three phase Ⅱ studies assessing the minimally invasive ablation of localized prostate cancer[J]. World J Urol, 2015, 33(7): 945-953.
[32] Azzouzi AR, Vincendeau S, Barret E, et al.Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase 3, randomised controlled trial[J]. Lancet Oncol, 2017, 18(2): 181-191.
[33] Lauwerends LJ, van Driel PBAA, Baatenburg de Jong RJ, et al. Real-time fluorescence imaging in intraoperative decision making for cancer surgery[J]. Lancet Oncol, 2021, 22(5):e186-e195.
[34] van Beurden F, van Willigen DM, Vojnovic B, et al. Multi-wavelength fluorescence in image-guided surgery, clinical feasibility and future perspectives[J]. Mol Imaging, 2020, 19: 1536012120962333.
[35] Kularatne SA, Thomas M, Myers CH,et al.Evaluation of novel prostate-specific membrane antigen-targeted near-infrared imaging agent for fluorescence-guided surgery of prostate cancer[J]. Clin Cancer Res, 2019, 25(1): 177-187.
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