目的 研究磁共振T2加权成像(T2WI)结合弥散加权成像(DWI)对直肠癌术前分期的价值,以及其与病理的相关性。方法 纳入2020年6月—2023年6月就诊的208例影像学、病理资料完整直肠癌患者进行回顾性分析。所有患者在术前行直肠标准方案MRI检查,通过平扫和增强提示肿瘤的位置和大小,DWI信号测量肿瘤的表观弥散系数(ADC)值。对比T2WI单独和联合DWI对于直肠癌术前分期的诊断效能。获得不同病理分级肿瘤组织的平均及最小ADC值,分析两者与病理分级之间的相关性。结果 T2WI联合DWI对于T2、T3期直肠癌的诊断准确度高于T2WI单独评估,差异具有统计学意义(P<0.05)。低分化直肠癌平均及最小ADC值明显低于中、高分化直肠癌,差异有统计学意义(P<0.05),且最小ADC值与病理分级呈负相关(r=–0.422, P<0.05)。结论 T2WI联合DWI对于直肠癌分期的诊断效能好于单独应用T2WI;最小 ADC 值对于术前肿瘤的病理分级具有较好的应用价值。
Objective To study the value of magnetic resonance (MR) T2 weighted imaging (T2WI) combined with diffusion weighted imaging (DWI) in preoperative staging of rectal cancer and its correlation with pathology. Methods This retrospective analysis was conducted on 208 patients of rectal cancer with complete imaging and pathological data from June 2020 to June 2023. All patients underwent preoperative rectal standard protocol of MRI examination, with plain and enhanced scans indicating the location and size of the tumor and DWI signals measuring the apparent diffusion coefficient (ADC) value of the tumor. We compared the diagnostic efficacy of T2WI alone and the combination of T2WI and DWI, obtained the average and minimum ADC values of tumor tissues with different pathological grades, and analyzed the correlation between the two values and pathological grades. Results The diagnostic accuracy of combined T2WI and DWI for T2 and T3 stages of rectal cancer was significantly higher than that of T2WI alone (P<0.05). The average and minimum ADC values of low differentiated rectal cancer were significantly lower than those of medium and high differentiated rectal cancers (P<0.05), and the minimum ADC value was negatively correlated with pathological grade(r=–0.422, P<0.05). Conclusions The combination of T2WI and DWI has a higher diagnostic efficiency for rectal cancer than T2WI alone. In addition, the minimum ADC value has a good value for preoperative pathological grading of tumors.
[1] 郭婧,高洁,郭世欣,等.T_(2)WI联合DWI用于直肠癌的诊断,术前分期效能及rADC,ADC值与患者临床特征的相关性[J].生物医学工程与临床,2023,27(1):6.
[2] 林燕,林晨阳,王晓瑜,等.高分辨率MRI与DWI在直肠癌术前分期与分级的应用研究[J].中国CT和MRI杂志,2023,21(3):147-149.
[3] 胡飞翔,岳亚丽,彭卫军,等.DWI联合T2WI在鉴别T2和T3期直肠癌术前分期中的应用价值[J].放射学实践,2021,36(4):507-513.
[4] 李春涛,左新会,王化凡.MRI常规成像序列结合DWI对直肠癌术前TN分期的诊断价值[J].深圳中西医结合杂志,2022,32(15):57-59.
[5] 倪建,毛庆杰,杨志勇.DCE-MRI定量分析联合DWI影像学检查对直肠癌术前临床分期的诊断价值[J].中国CT和MRI杂志,2021,19(9):4.
[6] 郎开放,李丹,郝俊宁.MRI DWI联合T2WI在T2和T3期直肠癌术前分期中的应用价值分析[J].中国肛肠病杂志,2022,42(2):2.
[7] 王绍凯. 高分辨率磁共振成像结合增强扫描在直肠癌术前T分期中的应用及其临床价值探讨[J].中国药物与临床,2020,20(23):3911-391
[8] 龚文峰. MRI T2WI联合DWI检查对老年直肠癌N分期术前诊断准确率的影响[J].内蒙古医学杂志,2021,53(10):1182-1184.
[9] 陈群中,顾浩玉,廖海波,等.DWI联合高分辨T2WI在直肠癌术前分期中的应用[J].广东医科大学学报,2022,40(6):660-663.
[10] 郭鑫,冯赟,伏红超,等.分析T2WI联合DWI在老年直肠癌患者术前TN分期中的临床价值[J].贵州医药,2022,46(2):212-213.
[11] 文大光,胡斯娴,李真林,等.基于T2WI与RS-EPI DWI影像组学特征的自动化机器学习模型预测直肠癌术前T分期的价值[J].四川大学学报(医学版),2021,52(4):8.