食管癌脉管瘤栓的相关因素分析

外科研究与新技术 ›› 2016, Vol. 5 ›› Issue (2): 108-110.

食管癌脉管瘤栓的相关因素分析

顾向森¹,周凯¹,何小勇¹,张杨杨²,周悦³

1. 江苏扬州市江都区人民医院
2. 南京医科大学第一附属医院，心胸外科
3. 南京医科大学第一附属医院胸外科

收稿日期:2016-03-02 修回日期:2016-04-01 出版日期:2016-06-28 发布日期:2016-09-13
通讯作者: 周悦 E-mail:chirurgeonzhouyue@163.com

Related factors of vascular tumor embolus in esophageal carcinoma

Received:2016-03-02 Revised:2016-04-01 Online:2016-06-28 Published:2016-09-13

摘要/Abstract

摘要： 目的：探讨食管癌合并脉管瘤栓患者的临床病理特点。方法：回顾性分析535例食管癌患者的病理资料及临床特点。结果：535例食管癌患者中有125例发现脉管瘤栓。肿瘤低分化较高分化更易发生脉管瘤栓，统计有显著性意义（P?0.01）；肿瘤浸润深度越深，淋巴结转移数目越多，脉管瘤栓发生率越高，统计有显著性意义（P?0.01）。单因素分析结果显示，脉管瘤栓、肿瘤分化程度、肿瘤浸润深度、淋巴结分期均对患者预后有影响（P?0.01）。结论：食管癌脉管瘤栓与肿瘤的分化程度、浸润深度及淋巴结转移数目有相关关系。脉管瘤栓是影响食管癌患者预后的危险因素。

关键词: 食管癌, 脉管瘤栓, 预后

Abstract: Objective: To investigate the clinical pathological characteristics of esophageal carcinoma complicated with vascular tumor embolus (VTE). Methods: The pathological data and clinical features of 535 patients with esophageal carcinoma were analyzed retrospectively. Results: There were 125 cases with VTE among 535 cases of esophageal carcinoma. The VTE is more likely to occur in poorly differentiated tumors than in high differentiated tumors, the difference is statistically significant（P?0.01）. The occurrence of VTE was closely related to the depth of tumor invasion and the number of lymph node metastasis, the statistics have significant（P?0.01）.The univariate regression analysis showed that VTE, the degree of tumor differentiation, the depth of invasion and lymph node staging were prognostic factors of patients with esophageal cancer. Conclusions: There is obvious relationship among the degree of tumor differentiation, the depth of invasion and the number of lymph node metastasis for VTE in esophageal cancer. VTE is a risk factor for prognosis of esophageal carcinoma.

Key words: Esophageal carcinoma, Vascular tumor embolus, Prognosis

顾向森周凯何小勇张杨杨周悦. 食管癌脉管瘤栓的相关因素分析[J]. 外科研究与新技术, 2016, 5(2): 108-110.

参考文献

[1]. 李林，柳硕岩，朱坤寿，等．早期食管癌淋巴转移规律与预后分析[J]．中华肿瘤杂志，2009，31（3）：226-229.
[2]. 祝淑钗，宋长亮，沈文斌，等．食管癌根治性切除术后患者预后的影响因素分析[J]．中华肿瘤杂志，2012，34（4）：281-286.
[3]. 李春海，李克勤．肿瘤微血管生成的机制与肿瘤侵袭和转移[J]．中华肿瘤杂志，2002，22（3）：181-183．
[4]. 刘志才，管福顺，郭建庄，等. 食管贲门癌脉管瘤栓与病理相关因素分析[J].癌症，2002，21(5)：530-532.
[5]. Del CJ, Corte MD, Alvarez A, et al. Lymphatic and/or blood vessel invasion in gastric cancer: relationship with clinicopathological parameters, biological factors and prognostic significance[J]. J Cancer Res Clin Oncol. 2008, 134(2):153-161.
[6]. Tsai TJ, Chau GY, Lui WY, et al. Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma[J]. Surgery. 2000, 127(6):603-608.
[7]. 吴孟超，吴在德. 黄家驷外科学[M].第七版.北京：人民卫生出版社，2008：2100.
[8]. Wang YD，Wu P，Mao JD，et al. Relationship between vascular invasion and microvessel density and micrometastasis[J]. World J Gastroenterol，2007，13（46）：6269-6273.
[9]. Mori D, Yamasaki F, Shibaki M, et al. Lateral peritumoral lymphatic vessel invasion can predict lymph node metastasis in esophageal squamous cell carcinoma[J]. Mod Pathol. 2007, 20(6):694-700.
[10]. Roma AA, Magi-Galluzzi C, Kral MA, et al. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma[J]. Mod Pathol. 2006, 19(3):392-398.
[11]. Wong SY, Haack H, Crowley D, et al. Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis[J]. Cancer Res. 2005, 65(21):9789-9798.
[12]. Agarwal B, Saxena R, Morimiya A, et al. Lymphangiogenesis does not occur in breast cancer[J]. Am J Surg Pathol. 2005, 29(11):1449-1455.
[13]. 李斌，相加庆，张亚伟，等. 食管癌淋巴结转移特点及其危险因素[J]. 中华胃肠外科杂志，2011（14）：711-714.
[14]. Sgourakis G，Gockel I，Lang H. Endoscopic and surgical resection of T1a/T1b esophageal neoplasms：a systematic review[J]. World J Gastroenterol，2013，19 （9）：1424-1437.
[15]. 霍小东，王洪江，庞作良，等. 339例中晚期胸段食管鳞癌术后生存评价及预后因素分析[J]. 实用肿瘤杂志，2010，25 （3）：273-277.