PVAT介导NO/NOS在脓毒血症患者血管舒缩活动中的作用研究进展

doi:10.3969/j.issn.2095-378X.2023.01.016

摘要/Abstract

摘要： 脓毒血症是一种严重的致命性疾病,多种机制参与其发生及演进过程。血管周围脂肪组织（perivascular adipose tissue, PVAT）作为心血管疾病中的重要参与者,与血管关系密切,同时可分泌多种活性物质参与血管舒缩活动的改变。一氧化氮（nitric oxide, NO）及一氧化氮合酶（nitric oxide synthase, NOS）是重要的舒血管物质。本综述通过回顾既往文献资料,对PVAT介导NO/NOS在脓毒症中血管张力调节的机制做一探讨,以期有助于后续的研究实践及临床工作。

关键词: 脓毒症, 血管周围脂肪组织, 一氧化氮, 一氧化氮合酶, 血管张力

Abstract: Sepsis is a serious and fatal disease, and many mechanisms are involved in its occurrence and development. Perivascular adipose tissue (PVAT), as an important participant in cardiovascular disease, is closely related to blood vessels, and can secrete a variety of active substances to participate in the changes of vasomotor activity. Nitric oxide (NO) and nitric oxide synthase (NOS) are important vasodilators. By reviewing previous literature, we explored the mechanism of PVAT-mediated NO/NOS regulation in vascular tone in sepsis, in the hope of contributing to the follow-up research and clinical practice.

Key words: Sepsis, Perivascular adipose tissue, Nitric oxide, Nitric oxide synthase, Vasotensin

中图分类号:

R365

李堃, 齐然, 刘南斌. PVAT介导NO/NOS在脓毒血症患者血管舒缩活动中的作用研究进展[J]. 外科研究与新技术, 2023, 12(1): 60-65.

LI Kun, QI Ran, LIU Nanbin. Research progress on role of PVAT-mediated NO/NOS in vasomotor activity in patients with sepsis[J]. Surgical Research and New Technique, 2023, 12(1): 60-65.

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