紫草素-季铵盐壳聚糖水凝胶复合物促进糖尿病小腿创面愈合的临床研究

doi:10.3969/j.issn.2095-378X.2026.02.002

外科研究与新技术（中英文） ›› 2026, Vol. 15 ›› Issue (2): 102-106.doi: 10.3969/j.issn.2095-378X.2026.02.002

紫草素-季铵盐壳聚糖水凝胶复合物促进糖尿病小腿创面愈合的临床研究

杨庆, 王庚启

上海中医药大学附属岳阳中西医结合医院创伤骨科, 上海 200437

收稿日期:2025-12-24 出版日期:2026-06-28 发布日期:2026-07-08
通讯作者: 王庚启,电子信箱：wanggengqi@126.com
作者简介:杨庆（1982—）,男,博士,副主任医师,从事临床创伤骨科工作
基金资助:
上海市中医药研究院科技发展项目（24YJS15）

Clinical study on promotion of diabetic lower leg wound healing by shikonin-quaternized chitosan hydrogel composite

YANG Qing, WANG Gengqi

Department of Orthopaedic Trauma, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

Received:2025-12-24 Online:2026-06-28 Published:2026-07-08

摘要/Abstract

摘要： 目的探讨紫草素（SK）溶液、紫草素-季铵盐壳聚糖复合水凝胶（SK-QPP）治疗糖尿病小腿创面的效果及安全性。方法选取2025年1—12月收治的60例糖尿病所致小腿创面患者,随机分为SK组、SK-QPP组及对照组,每组各20例。对照组行常规处理,另两组清创后分别外敷SK溶液、SK-QPP,比较三组创面愈合率、有效率、愈合时间及不良反应。结果治疗1、2、4周,愈合率SK-QPP组>SK组>对照组（P<0.05）;创面愈合时间SK-QPP组（16.24±2.87） d<SK组（19.68±3.12） d<对照组（28.53±4.21） d（P<0.05）;SK-QPP组治疗有效率最高（95.0%）,>SK组（85.0%）>对照组（65.0%）（P<0.05）;三组间不良反应发生率差异无统计学意义（P>0.05）。结论 SK溶液及SK-QPP均能提升糖尿病小腿创面愈合效果、缩短疗程且安全性好,且SK-QPP疗效更优,值得推广。

关键词: 紫草素, 紫草素-季铵盐壳聚糖水凝胶复合物, 糖尿病创面, 创面愈合, 愈合率

Abstract: Objective To investigate the efficacy and safety of shikonin （SK） solution and shikonin-quaternized chitosan hydrogel composite （SK-QPP） in the treatment of diabetic lower leg wounds. Methods Sixty patients with diabetic lower leg wounds admitted to our hospital from January to December 2025 were selected and randomly divided into an SK group, an SK-QPP group, and a control group, with 20 cases in each group. The control group received routine treatment, while the other two groups were treated with topical SK solution and SK-QPP after debridement, respectively. Wound healing rate, effective rate, healing time, and adverse reactions were compared among the three groups. Results At 1, 2 and 4 weeks of treatment, the wound healing rate rank was SK-QPP group > SK group > control group （P<0.05）. The wound healing time was （16.24±2.87） d in the SK-QPP group, （19.68±3.12） d in the SK group, and （28.53±4.21） d in the control group （P<0.05）. The effective rate was the highest in the SK-QPP group （95.0%）, followed by the SK group （85.0%） and the control group （65.0%）（P<0.05）. There were no significant differences in adverse reactions among the three groups （P>0.05）. Conclusion Both SK solution and SK-QPP can improve the healing effect of diabetic lower leg wounds, shorten the treatment course, and show good safety, and SK-QPP has better efficacy and is worthy of clinical promotion.

Key words: Shikonin, Shikonin-quaternized chitosan hydrogel composite, Diabetic wound, Wound healing, Healing rate

中图分类号:

杨庆, 王庚启. 紫草素-季铵盐壳聚糖水凝胶复合物促进糖尿病小腿创面愈合的临床研究[J]. 外科研究与新技术（中英文）, 2026, 15(2): 102-106.

参考文献

[1] Wang R, Gu S, Kim YH, et al.Diabetic wound repair: from mechanism to therapeutic opportunities[J]. Med Comm (2020),2025,6(10):e70406.
[2] Thanigaimani S, Jin H, Ahmad U, et al.Comparative efficacy of growth factor therapy in healing diabetes-related foot ulcers: a network meta-analysis of randomized controlled trials[J]. Diabetes Metab Res Rev,2023,39(5):e3670.
[3] Wang X, Huo H, Zhong Y,et al.Synergistic antimicrobial glycyrrhizic acid-based functional biosensing composite for sensitive glucose monitoring and collaborative wound healing[J]. Adv Healthc Mater,2024,13(20):e2400580.
[4] Xin H, Cai Z, Hao J, et al.Macro/microgel-encapsulated, biofilm-armored living probiotic platform for regenerating bacteria-infected diabetic wounds[J]. Adv Healthc Mater,2025,14(7):e2403476.
[5] 江周影,谢鹏发,郭嘉秀,等.乙酰紫草素药理作用的研究进展[J]. 中国医药导报,2023,20(16):54-57.
[6] Liu F, Xu X, Sun T.Vascular endothelial growth factor accelerates healing of foot ulcers in diabetic rats via promoting M2 macrophage polarization[J]. Diabet Med, 2024,41(9):e15388.
[7] Xue C, Dou J, Zhang S, et al.Shikonin potentiates skin wound healing in Sprague-Dawley rats by stimulating fibroblast and endothelial cell proliferation and angiogenesis[J]. J Gene Med,2024,26(1):e3633.
[8] Wang X, Song R, Johnson M, et al.An injectable chitosan-based self-healable hydrogel system as an antibacterial wound dressing[J]. Materials (Basel),2021,14(20):5956.
[9] Li H, Wei S, Ling Q, et al.Nanozyme-reinforced hydrogel spray as a reactive oxygen species-driven oxygenator to accelerate diabetic wound healing[J]. Adv Mater,2025, 37(34):e2504829.
[10] Teng L, Maqsood M, Zhu M, et al.Exosomes derived from human umbilical cord mesenchymal stem cells accelerate diabetic wound healing via promoting M2 macrophage polarization, angiogenesis, and collagen deposition[J]. Int J Mol Sci.2022,23(18):10421.
[11] 林艳巧,刘雅芳,吴含章,等.紫草的性味归经、功效及用药禁忌考证[J]. 环球中医药,2023,16(10):2074-2077.
[12] 袁美杰,朱旭莹,史宏硕,等. 紫草素治疗糖尿病足溃疡的疗效及基于网络药理学的作用机制[J]. 世界中医药,2025,20(13):2239-2248.
[13] Song Y, Ding Q, Hao Y, et al.Pharmacological effects of shikonin and its potential in skin repair: a review[J]. Molecules,2023,28(24):7950.
[14] 钱雪,李海涛,曾万祥,等.紫草化学成分、药理作用及产品应用研究进展[J]. 中国野生植物资源,2021,40(3):52-56.
[15] Song X, Li D, Guo T, et al.Hyaluronan-based hydrogel achieves in situ administration of protocatechualdehyde to polarize macrophages to M2 phenotype for diabetic wound therapy[J]. Int J Biol Macromol,2025,318(Pt3):145118.
[16] Segneanu AE, Bejenaru LE, Bejenaru C, et al.Advancements in hydrogels: a comprehensive review of natural and synthetic innovations for biomedical applications[J]. Polymers (Basel), 2025,17(15):2026.
[17] 贾颖,王佳敏,王世晖,等.复方紫草凝胶外用制剂的抗炎与抑菌作用研究[J]. 日用化学工业,2020,50(12):848-853.
[18] 单文汐,李恒,曹政,等.三维打印制备载左旋紫草素的甘露醇-海藻酸钙水凝胶及体外释药和抗菌性能研究[J]. 空军军医大学学报,2025,46(10):1300-1305.
[19] Ho J, Yue D, Cheema U, et al.Innovations in stem cell therapy for diabetic wound healing[J]. Adv Wound Care (New Rochelle),2023,12(11):626-643.
[20] Yan C, Chen J, Wang C, et al.Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis[J]. Drug Deliv,2022,29(1):214-228.
[21] 简有源,张建丹,卢占洲.负压封闭引流技术结合肌瓣转移游离植皮在难愈性创面修复中对患者疼痛及外观满意度影响分析[J]. 外科研究与新技术(中英文),2024,13(4):323-326.

紫草素-季铵盐壳聚糖水凝胶复合物促进糖尿病小腿创面愈合的临床研究

Clinical study on promotion of diabetic lower leg wound healing by shikonin-quaternized chitosan hydrogel composite

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