纳米科技在骨关节炎影像中的临床应用前景和机遇

doi:10.3969/j.issn.2095-378X.2022.01.001

摘要/Abstract

摘要： 骨关节炎（osteoarthritis, OA）是最常见的骨关节病变,目前认为OA不再单纯只是一种退行性病变,而是一种系统性、代谢性、炎症性疾病。OA是老年人残疾的主要原因和社会成本的来源之一。许多新技术和材料正在进行临床前开发,以解决这一多因素疾病。在诊断方面,用于MRI、CT和PA的纳米造影剂提供了更多关于软骨结构和病变定性和定量的信息,这是早期OA的已知生物标记物。纳米医学发展的机遇,以及成像和诊断的未来前景极其广阔。

关键词: 软骨成像, 高级成像, 纳米科技

Abstract: Osteoarthritis （OA） is the most common bone and joint disease. At present, it is considered no longer just a degenerative disease, but a systemic, metabolic, and inflammatory disease. OA is the main cause of disability of the elderly and one of the sources of social costs. Many new technologies and materials are under preclinical development to address this multifactorial disease. In terms of diagnosis, nano contrast agents for MRI, CT, and PA provide a lot of qualitative and quantitative information about cartilage structure and lesions, which are known biomarkers of OA. The opportunities for the development of nano medicine and the prospects of imaging and diagnosis based on nanotechnology are extremely broad.

Key words: Cartilage imaging, Advanced imaging, Nanotechnology

中图分类号:

R445.2

鹿蓉, 陈爽. 纳米科技在骨关节炎影像中的临床应用前景和机遇[J]. 外科研究与新技术, 2022, 11(1): 1-8.

LU Rong, CHEN Shuang. Clinical prospects and opportunities for nanotechnology applied to imaging of osteoarthritis[J]. Surgical Research and New Technique, 2022, 11(1): 1-8.

参考文献

[1] Turkiewicz A, Petersson IF, Björk J, et al.Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032[J]. Osteoarthritis Cartilage, 2014, 22(11): 1826-1832.
[2] 薛庆云, 王坤正, 裴福兴, 等. 中国40岁以上人群原发性骨关节炎患病状况调查[J]. 中华骨科杂志, 2015, 35(12): 1206-1212.
[3] Sharma L.Osteoarthritis of the knee[J]. N Engl J Med, 2021, 384(1): 51-59.
[4] Chalian M, Li X, Guermazi A, et al.The QIBA profile for MRI-based compositional imaging of knee cartilage[J]. Radiology, 2021, 301(2): 423-432.
[5] Safiri S, Kolahi AA, Smith E, et al.Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017[J]. Ann Rheum Dis, 2020, 79(6): 819-828.
[6] Bajpayee AG, Grodzinsky AJ.Cartilage-targeting drug delivery: can electrostatic interactions help?[J]. Nat Rev Rheumatol, 2017, 13(3):183-193.
[7] 中华医学会骨科学分会关节外科学组, 中国医师协会骨科医师分会骨关节炎学组,国家老年疾病临床医学研究中心(湘雅医院),等.中国骨关节炎诊疗指南(2021年版)[J]. 中华骨科杂志, 2021, 41(18):1291-1314.
[8] Oei E, Wick M, Müller-Lutz A, et al.Cartilage imaging: techniques and developments[J]. Semin Musculoskelet Radiol, 2018, 22(2): 245-260.
[9] Roemer FW, Demehri S, Omoumi P, et al.State of the art: imaging of osteoarthritis—revisited 2020[J]. Radiology, 2020, 296(1): 5-21.
[10] Mansur HS, Mansur AAP, Curti E, et al.Bioconjugation of quantum-dots with chitosan and N,N,N-trimethyl chitosan[J]. Carbohydr Polym, 2012, 90(1): 189-196.
[11] Labens R, Daniel C, Hall S, et al.Effect of intra-articular administration of superparamagnetic iron oxide nanoparticles (SPIONs) for MRI assessment of the cartilage barrier in a large animal model[J]. PLoS One, 2017, 12(12): e0190216.
[12] Yarmola EG, Shah Y, Arnold DP, et al.Magnetic capture of a molecular biomarker from synovial fluid in a rat model of knee osteoarthritis[J]. Ann Biomed Eng, 2016, 44(4): 1159-1169.
[13] Lu R, Zhang Y, Tao H, et al.Gadolinium-hyaluronic acid nanoparticles as an efficient and safe magnetic resonance imaging contrast agent for articular cartilage injury detection[J]. Bioact Mater, 2020, 5(4): 758-767.
[14] Freedman JD, Lusic H, Snyder BD, et al.Tantalum oxide nanoparticles for the imaging of articular cartilage using X-ray computed tomography: visualization of ex vivo/in vivo murine tibia and ex vivo human index finger cartilage[J]. Angew Chem Int Ed Engl, 2014, 53(32): 8406-8410.
[15] Honkanen MKM, Saukko AEA, Turunen M J, et al.Triple contrast CT method enables simultaneous evaluation of articular cartilage composition and segmentation[J]. Ann Biomed Eng, 2020, 48(2): 556-567.
[16] Saukko AEA, Honkanen JTJ, Xu W, et al.Dual contrast CT method enables diagnostics of cartilage injuries and degeneration using a single CT image[J]. Ann Biomed Eng, 2017, 45(12): 2857-2866.
[17] Zhou Y, Ni J, Wen C, et al.Light on osteoarthritic joint: from bench to bed[J]. Theranostics, 2022, 12(2): 542-557.
[18] Sun Y, Sobel ES, Jiang H.First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints[J]. Med Phys, 2011, 38(7): 4009-4017.
[19] Chen L, Ji Y, Hu X, et al.Cationic poly-l-lysine-encapsulated melanin nanoparticles as efficient photoacoustic agents targeting to glycosaminoglycans for the early diagnosis of articular cartilage degeneration in osteoarthritis[J]. Nanoscale, 2018, 10(28): 13471-13484.
[20] Ahmed K, Saikat A, Moni A, et al.Lactoferrin: potential functions, pharmacological insights, and therapeutic promises[J]. J Adv Biotechnol Exp Ther, 2021, 4(2): 223.
[21] Scognamiglio F, Travan A, Borgogna M, et al.Development of biodegradable membranes for the delivery of a bioactive chitosan‐derivative on cartilage defects: A preliminary investigation[J]. J Biomed Mater Res, 2020, 108(7): 1534-1545.
[22] Samarasinghe RM, Kanwar RK, Kanwar JR.The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis[J]. Biomaterials, 2014, 35(26): 7522-7534.
[23] Tao W, He Z.ROS-responsive drug delivery systems for biomedical applications[J]. Asian Journal of Pharmaceutical Sciences, 2018, 13(2): 101-112.
[24] Xu X, Shi D, Shen Y, et al.Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin[J]. Arthritis Res Ther, 2015, 17(1): 20.
[25] Mohan G, Magnitsky S, Melkus G, et al.Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study: kartogenin treatment for OA[J]. J Orthop Res, 2016, 34(10): 1780-1789.
[26] Fan W, Li J, Yuan L, et al.Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis[J]. Drug Delivery, 2018, 25(1): 1004-1012.
[27] Jiang T, Kan H-M, Rajpura K, et al.Development of targeted nanoscale drug delivery system for osteoarthritic cartilage tissue[J]. J Nanosci Nanotechnol, 2018, 18(4): 2310-2317.
[28] Whitmire RE, Wilson DS, Singh A, et al.Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins[J]. Biomaterials, 2012, 33(30): 7665-7675.
[29] Liu X, Corciulo C, Arabagian S, et al.Adenosine-Functionalized biodegradable PLA-b-PEG nanoparticles ameliorate osteoarthritis in rats[J]. Sci Rep, 2019, 9(1): 7430.
[30] DiDomenico CD, Lintz M, Bonassar LJ. Molecular transport in articular cartilage—what have we learned from the past 50 years?[J]. Nat Rev Rheumatol, 2018, 14(7): 393-403.
[31] Kundrotas G, Karabanovas V, Pleckaitis M, et al.Uptake and distribution of carboxylated quantum dots in human mesenchymal stem cells: cell growing density matters[J]. J Nanobiotechnology, 2019, 17(1): 39.
[32] Yoshioka T, Mishima H, Kaul Z, et al.Fate of bone marrow mesenchymal stem cells following the allogeneic transplantation of cartilaginous aggregates into osteochondral defects of rabbits[J]. J Tissue Eng Regen Med, 2011, 5(6): 437-443.
[33] Markides H, Newell KJ, Rudorf H, et al.Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model[J]. Stem Cell Res Ther, 2019, 10(1): 25.
[34] Van Buul GM, Kotek G, Wielopolski P A, et al.Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides[J]. PLoS One, 2011, 6(2): e17001.
[35] Chen J, Wang F, Zhang Y, et al.In vivo tracking of superparamagnetic iron oxide nanoparticle labeled chondrocytes in large animal model[J]. Ann Biomed Eng, 2012, 40(12): 2568-2578.
[36] Pang P, Wu C, Shen M, et al.An MRI-visible non-viral vector bearing GD2 single chain antibody for targeted gene delivery to human bone marrow mesenchymal stem cells[J]. PLoS One, 2013, 8(10): e76612.
[37] Theruvath AJ, Nejadnik H, Lenkov O, et al.Tracking stem cell implants in cartilage defects of minipigs by using ferumoxytol-enhanced MRI[J]. Radiology, 2019, 292(1): 129-137.
[38] Chen Z, Yan C, Yan S, et al.Non-invasive monitoring of in vivo hydrogel degradation and cartilage regeneration by multiparametric MR imaging[J]. Theranostics, 2018, 8(4): 1146-1158.
[39] Zare S, Mehrabani D, Jalli R, et al.MRI-tracking of dental pulp stem cells in vitro and in vivo using dextran-coated superparamagnetic iron oxide nanoparticles[J]. J Clin Med, 2019, 8(9):1418.
[40] Su JY, Chen SH, Chen YP, et al.Evaluation of magnetic nanoparticle-labeled chondrocytes cultivated on a type II collagen-chitosan/poly(lactic-co-glycolic) acid biphasic scaffold[J]. Int J Mol Sci, 2017, 18(1):87.