N末端脑钠肽前体在心脏外科临床应用的进展

摘要/Abstract

摘要： N末端脑钠肽前体(NT-proBNP)是由心室肌合成并释放的肽类，当心室壁张力变化改变时其释放增多。NT-proBNP被认为心力衰竭诊断和评估预后的生物标记物。研究表明NT-proBNP对冠心病(coronary artery disease，CAD)诊断及其预后具有临床应用价值。NT-proBNP在心脏外科特别是冠状动脉旁路移植术(coronary artery bypass grafting，CABG)及心脏瓣膜手术中的临床价值逐渐引起了人们的注意。本文就NT-proBNP在心脏外科领域中的临床应用及研究进展做一综述。

关键词: N末端脑钠肽前体, 冠心病, 冠状动脉旁路移植术, 心脏瓣膜置换术

Abstract: N-terminal pro-brain natriuretic peptide(NT-proBNP) is a kind of peptide which synthesized and secreted by ventricular muscle.When the stress of ventricular wall changes,NT-proBNP has an increasing secretion.NT-proBNP is recognized as a biomarker which can be used in the diagnosis of heart failure and prognosis prediction.Current studies have shown that NT-proBNP has clinical application value in the diagnosis and prognosis of coronary artery disease (CAD).The clinical value of NT-proBNP in cardiac surgery,especially in coronary artery bypass grafting (CABG) and cardiac valvular surgery gradually attracts popular’s attention.This article reviews the clinical application and research progress of NT-proBNP in cardiac surgery field.

Key words: N-terminal pro-brain natriuretic peptide, Coronary artery disease, Coronary artery bypass grafting, Cardiac valvular replacement

中图分类号:

R654.2

顾畅(综述)，张杨杨(审校). N末端脑钠肽前体在心脏外科临床应用的进展[J]. 外科研究与新技术, 2013, 2(3): 180-184.

GU Chang, ZHANG Yang-yang. Progress of clinical application for N-terminal pro-brain natriuretic peptide in cardiac surgery[J]. Surgical Research and New Technique, 2013, 2(3): 180-184.

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