重视抗HBV在肝癌治疗中的作用

外科研究与新技术 ›› 2013, Vol. 2 ›› Issue (4): 225-228.

重视抗HBV在肝癌治疗中的作用

王捷

中山大学孙逸仙纪念医院肝胆外科，广州 510120

出版日期:2013-12-28 发布日期:2013-04-25
作者简介:王捷,男,(1957-),教授、博士生导师,主要研究高位肝门部胆管癌、复杂性再次肝胆管结石、不阻断肝血流条件下肝中叶巨大复杂肝癌切除、复发性肝癌再切除、胰腺癌切除以及门脉高压症时肝脾移植治疗。
基金资助:
国家重大专项课题(2012ZX10002-016),广东省科技攻关项目(2008A030201005),中山大学临床研究5010项目(2010009)

Anti-HBV playing an important role in therapy of hepatocellular carcinoma

WANG Jie

Department of Hepato-Biliary Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China

Online:2013-12-28 Published:2013-04-25

摘要/Abstract

摘要： 乙型肝炎病毒感染是我国肝癌发生最主要的危险因素，其复制水平也影响着肝癌患者术后并发症的发生。大量的研究已经证实HBV-DNA 复制也可以导致肝癌术后复发率的增高，因此，一些临床研究致力于抗HBV治疗能否有效预防肝癌的术后复发。目前大多数的研究表明，抗HBV治疗可以降低肝癌术后复发率，而部分研究结果则认为不能降低肿瘤的复发率，但是可以延长病人的生存时间。对于HBV相关性肝癌，抗HBV治疗无论是在肝癌围手术期的处理还是在预防肝癌术后复发方面，在肝癌治疗的整个过程中均扮演了重要的角色。因此，在肝癌的临床治疗中，必须重视抗HBV的治疗。

关键词: 原发性肝癌, 乙型肝炎病毒, 疾病治疗

Abstract: Hepatitis B virus infection (HBV) is the major risk factor for hepatocarcinogenesis in China,and the HBV-DNA level also influences the postoperative complications ratio.A lot of research has confirmed that HBV-DNA replication could lead to the tumor recurrence after liver resection.Some clinical research aimed to find whether anti-HBV therapy can prevent the relapse of hepatocellular carcinoma (HCC).At present,majority study confirm that anti-HBV therapy can reduce tumor recurrence ratio of HCC,but some researches find it is useless for the relapse preventing,however,it can prolong the patients survival period.Above all,as for HBV related HCC,anti-HBV therapy plays an important role in the whole HCC therapy process including perioperative treatment and HCC relapse prevention.So,we must pay attention to anti-HBV therapy in HCC treatment.

Key words: Hepatocellular carcinoma, Hepatitis B virus, Disease treatment

中图分类号:

R735.7

王捷. 重视抗HBV在肝癌治疗中的作用[J]. 外科研究与新技术, 2013, 2(4): 225-228.

WANG Jie. Anti-HBV playing an important role in therapy of hepatocellular carcinoma[J]. Surgical Research and New Technique, 2013, 2(4): 225-228.

参考文献

[1]Oliveri F,Brunetto MR,Actis GC,et al.Pathobiology of chronic hepatitis virus infection and hepatocellular carcinoma (HCC) [J].Ital J Gastroenterol.1991,23(8):498-502.
[2] Hirohashi K,Shuto T,Kubo S,et al.Prognostic factors after recurrence of resected hepatocellular carcinoma associated with hepatitis C virus[J].J Hepatobiliary Pancreat Surg,2001,8(1):81-86.
[3] 陈涛,区庆嘉,陈积圣.中国肝癌病人乙型、丙型、庚型肝炎病毒感染及临床特点[J].中华普通外科杂志,1998,13(10):368.
[4] 陈涛,区庆嘉,陈积圣,等.肝癌病人乙型肝炎病毒复制状态及对外科干预的反应[J].中国实用外科杂志,1997,17(10):587-589.
[5] Beasley RP.Hepatitis B virus:the major etiology of hepatocellular carcinoma[J].Cancer,1988,61(10):1942-1945.
[6] 王辉,区庆嘉,陈涛,等.拉米夫定对肝癌围手术期乙肝病毒活跃的防治研究[J].中国实用外科杂志,2001,21(1):95-97.
[7] Dan JQ,Zhang YJ,Huang JT,et al.Hepatitis B virus reactivation after radiofrequency ablation or hepatic resection for HBV-related small hepatocellular carcinoma:A retrospective study[J].EJSO,2013,39 (6):865-872.
[8] ThiaTJ,Lui HF,Ooi LL,et al.A study into the risk of exacerbation of chronic hepatitis B after liver resection for hepatocellular carcinoma.J Gastrointest Surg[J].2007,11(5):612-618.
[9] Di-Peng Ou,Lian-Yue Yang,Geng-Wen Huang,et al.Clinical analysis of the risk factors for recurrence of HCC and itsrelationship with HBV[J].World J Gastroenterol,2005,11(14):2061-2066.
[10] Kubo S,Hirohashi K,Tanaka H,et al.Virologic and biochemical changes and prognosis after liver resection for hepatitis B virus-related hepatocellular carcinoma[J].Dig Surg,2001,18(1):26-33.
[11] Poon RT,Wong J.Long-term disease-free survival after resection of hepatocellular carcinoma:both tumor behavior and surgeon's performance are important determinants[J].Ann Surg Oncol,2003,10(8):834-836.
[12] Yao FY,Kinkhabwala M,LaBerge JM,et al.The impact of pre-operative loco-regional therapy on outcome after liver transplantation for hepatocellular carcinoma[J].Am J Transplant,2005,5(4 Pt 1):795-804.
[13] Qi Zhang,Guangwen Cao.Genotypes,mutations,and viral load of hepatitis B virus and the risk of hepatocellular carcinoma[J].Hepat Mon,2011,11(2):86-91.
[14] RY.Miao,HT.Zhao,HY.Yang,et al.Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma:a meta-analysis[J].World Journal of Gastroenterology,2010,16(23):2931-2942.
[15] Kuzuya T,Katano Y,Kumada T,et al.Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma[J].Journal of Gastroenterology and Hepatology,2007,22(11):1929-1935.
[16] Urata Y,Kubo S,Takemura S,et al.Effects of antiviral therapy on long-term outcome after liver resection for hepatitis B virus-related hepatocellular carcinoma[J].J Hepatobiliary Pancreat Sci,2012,19(8):685-696.
[17] LiN,Lai ECH,Shi J,et al.A comparative study of antiviral therapy after resection of hepatocellular carcinoma in the immune-active phase of hepatitis B virus infection[J].Annals of Surgical Oncology,2010,17(1):179-185.
[18] 程树群,吴孟超,陈汉,等.拉米夫定结合胸腺肽治疗对合并活动性肝炎肝癌术后复发的影响[J].中华肿瘤杂志,2005,27(2):114-116.欢迎投稿欢迎订阅