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外科研究与新技术（中英文）

外科研究与新技术 ›› 2018, Vol. 7 ›› Issue (4): 238-240.doi: 10.3969/j.issn.2095-378X.2018.04.004

• 论著 • 上一篇    下一篇

加速康复外科治疗改善结直肠癌患者营养及免疫功能

包增涛, 唐强, 史文超, 周晓敏, 陈慧玉   

  1. 连云港市第一人民医院胃肠外科,连云港 222000
  • 收稿日期:2018-10-16 出版日期:2018-12-28 发布日期:2019-12-09
  • 通讯作者: 陈慧玉,电子信箱:sharker911@163.com
  • 作者简介:包增涛(1987—),男,硕士,主治医师,从事临床胃肠道肿瘤工作

Enhanced recovery after surgery improves nutrition and immune function of patients with colorectal cancer

BAO Zengtao, TANG Qiang, SHI Wenchao, ZHOU Xiaomin, CHEN Huiyu   

  1. Department of Gastrointestinal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222000, China
  • Received:2018-10-16 Online:2018-12-28 Published:2019-12-09

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摘要： 目的 观察加速康复外科治疗对结直肠癌患者营养状况及免疫功能的影响。方法 将2016年3月—2018年3月64例结直肠癌患者随机分为对照组(33例)与观察组(31例),观察组予以加速康复外科理念治疗,对照组施行常规治疗。术前,术后1 d、3 d、7 d分别检测两组患者血清白蛋白(ALB)、前白蛋白(PA)、铁蛋白(SF)等营养指标和免疫球蛋白IgA、IgG、IgM等体液免疫功能指标。结果 观察组PA除术后1 d明显低于术前水平(P<0.05)外,术后3 d、7 d均与术前水平比较无差异; 对照组术后3 d的PA、ALB、SF与术前比较具显著差异(P<0.05),术后7 d恢复至术前水平,观察组PA、ALB、SF变化幅度明显小于对照组(P<0.05)。两组术后免疫功能指标均发生变化,术后3 d明显低于术前水平(P<0.05),术后7 d恢复至术前水平,观察组IgA、IgG、IgM变化幅度亦小于对照组(P<0.05)。结论 加速康复外科治疗可改善结直肠癌患者营养状况和免疫功能。

关键词: 结直肠癌, 加速康复外科理念, 营养指标, 免疫功能

Abstract: Objective To observe the changes of nutrition and immune function indices of patients with colorectal cancer using enhanced recovery after surgery.Methods A total of 64 patients with colorectal cancer admitted from March 2016 to March 2018 were divided into control group (n=33) and observation group (n=31).The patients in the observation group received enhanced recovery after surgery; the patients in the control group received conventional treatment.The nutrition indices (ALB,PA,and SF) and immune indices (IgA,IgG,and IgM) of the two groups before surgery and 1 day,3 days,and 7 days after surgery were detected.Results In the observation group,except for a lower level 1 day after surgery (P<0.05),no differences in PA level were observed between 3 days or 7 days after surgery and before surgery.In the control group,the PA,ALB,and SF 3 days after surgery had statistical differences compared with before surgery(P<0.05) and returned to the preoperative level 7 days after surgery.The changes of ALB,PA,and SF levels of the observation group were smaller than those of the control group (P<0.05).The postoperative immune function indices of both groups changed,and the levels 3 days after surgery were lower than before (P<0.05),and returned to the preoperative level 7 days after surgery.The changes of IgA,IgG,and IgM levels of the observation group were smaller than those of the control group as well (P<0.05).Conclusion Enhanced recovery after surgery could relieve the nutritional status and immune function of patients with colorectal cancer.

Key words: Colorectal cancer, Enhanced recovery after surgery, Nutrition index, Immune function

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