关键词: 塞来昔布, 超前镇痛, 人工流产

Abstract: Objective To observe the clinical effect of celecoxib preemptive analgesia for painless abortion.Methods Eighty pregnant women in early pregnancy were randomly divided into celecoxib group (treatment group) and control group, 40 cases in each group.Treatment Group received oral celecoxib 400 mg at 2 h before operation for preemptive analgesia, while control group did not.Both groups were given intravenous fentanyl 0.05 mg + propofol 2.0 mg/kg, followed by propofol as needed.BP, HR, SPO₂, and RR were recorded before anesthesia (T₀), at disappearance of consciousness (T₁), at cervix expansion (T₂), at opening eyes by prompting (T₃), and at 1h after operation (T₄); induction time, recovery time, intraoperative total propofol dosage, intraoperative limb movement, glossoptosis, respiratory depression, intraoperative blood loss, and postoperative pain and other adverse reactions were recorded; VRS pain scores at 15, 30, and 60 min after surgery were recorded.Results There were no significant differences in BP, HR, SPO₂, and RR at the 5 time points (P>0.05).Treatment Group patients’ anesthesia recovery time was significantly shorter than that of control group patients’, and the total propofol dosage was less (P<0.05).There was no significant difference in intraoperative blood loss between the two groups (P>0.05).In treatment group, the incidence rates of glossoptosis and respiratory depression were significantly lower than those in control group (P<0.05).The pain scores of VRS in treatment group were significantly lower than those in control group at different time points after waking up (P<0.05).Conclusion Celecoxib preemptive analgesia for painless abortion can reduce intraoperative propofol dosage and postoperative pain, while not increase blood loss and the incidence of respiratory depression or other adverse reactions.

Key words: Celecoxib, Preemptive analgesia, Abortion