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外科研究与新技术（中英文）

外科研究与新技术 ›› 2023, Vol. 12 ›› Issue (2): 108-111.doi: 10.3969/j.issn.2095-378X.2023.02.008

• 论著 • 上一篇    下一篇

不同剂量利奈唑胺治疗脑外科术后肺部感染患者的药代动力学研究

郭莹莹, 庄海阳, 苏宝燕, 王佳坤   

  1. 福建省泉州市联勤保障部队第910医院药剂科, 福建 泉州 362000
  • 收稿日期:2023-05-09 发布日期:2023-09-08
  • 通讯作者: 王佳坤,电子信箱：761352798@qq.com
  • 作者简介:郭莹莹（1986—）,女,大学本科,药师,从事药事管理工作

Pharmacokinetic evaluation of different doses of linezolid in treatment of postoperative pulmonary infection in patients undergoing neurosurgery

GUO Yingying, ZHUANG Haiyang, SU Baoyan, WANG Jiakun   

  1. Department of Pharmacy, 910 Hospital of the Joint Logistics Support Force, Quanzhou 362000, Fujian, China
  • Received:2023-05-09 Published:2023-09-08

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摘要： 目的 研究不同剂量利奈唑胺治疗脑外科术后肺部感染患者的药代动力学。方法 选取2020年1月—2022年8月收治的脑外科术后肺部感染患者80例,根据利奈唑胺起始剂量不同区分为600 mg/d组（n=40）及1 200 mg/d组（n=40）。治疗4 d后,采集两组患者静脉血标本,采用高效液相色谱检测血浆中利奈唑胺给药间隔40%时间点浓度（C40%T）和给药间隔100%时间点浓度（C100%T）;治疗1周后,评估两组患者治疗效果。采用Pearson相关性分析利奈唑胺的血药浓度及临床疗效之间的相关性。结果 600 mg/d组患者的C40%T浓度明显高于1 200 mg/d组患者,C100%T浓度则明显低于1 200 mg/d组,差异具有统计学意义（P<0.05）;两组患者在40%T>4×MIC及100%T>MIC的药物效应动力学（PD）达标率比较上无明显差异,不具有统计学意义（P>0.05）;600 mg/d组患者治疗总有效率为67.50%,1 200 mg/d组患者治疗总有效率为72.50%,两组比较无明显差异,不具有统计学意义（P>0.05）;两组患者利奈唑胺的C40%T及C100%T浓度均与临床疗效呈现正相关性（均P<0.05）。结论 600 mg/d和1 200 mg/d利奈唑胺治疗脑外科术后肺部感染患者的PD达标率无明显差异,血药浓度与临床治疗效果呈现正相关性。

关键词: 脑外科术后, 肺部感染, 利奈唑胺, 血药浓度, 药代动力学

Abstract: Objective To study the pharmacokinetics of different doses of linezolid in the treatment of postoperative pulmonary infection in patients undergoing neurosurgery. Methods From January 2020 to August 2022, a total of 80 patients with pulmonary infection after brain surgery admitted were divided into 600 mg/d group （n=40） and 1 200 mg/d group （n=40） according to initial linezolid dose. After 4 days of treatment, venous blood samples of the two groups of patients were collected, and the plasma concentrations of linezolid at 40% time interval （C40%T） and 100% time interval （C100%T） were detected by high performance liquid chromatography. After one week of treatment, the treatment effectiveness of both groups of patients were evaluated. Pearson correlation analysis was conducted on the correlation between blood concentration and clinical efficacy of linezolid. Results The C40%T concentration in the 600 mg/d group was significantly higher than that in the 1200 mg/d group, while the C100%T concentration was significantly lower （P<0.05）. The two groups of patients showed no differences in PD target attainment rate of 40%T>4×MIC and 100%T>MIC （P>0.05）. The total effective rate of the 600 mg/d group was 67.50%, while that of the 1200 mg/d group was 72.50%, and there was no significant difference between the two groups （P>0.05）. The C40%T and C100%T of linezolid in both groups of patients showed a positive correlation with clinical efficacy （both P<0.05）. Conclusion There is no significant difference in the PD target attainment rate between 600 mg/d and 1200 mg/d linezolid in the treatment of postoperative pulmonary infection patients in neurosurgery. There is a positive correlation between blood drug concentration and clinical treatment efficacy.

Key words: Post neurosurgery, Pulmonary infection, Linezolid, Blood concentration, Pharmacokinetics

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