Abstract: Objective This study was to investigate the Relationship between Helicobactor Pylori infection and upper gastrointestinal hemorrhage caused by anti platelet therapy. Methods 565 patients taking enteric-coated aspilin and 531 patients taking clopidogrel in our hospital from January 2012 to Junuary 2014 were studyed. All patients were given Hp testing and divided into Hp-positive group and Hp-negative group. Rusults We found that the Hp-positive groups have the more possibility of bleeding than the Hp-negative groups（P＜0.05）. Conclusion Eradication of Helicobacter pylori is helpful to reduce the risk of the gastrointestinal tract bleeding.