Abstract: 【Abstact】 Objective To explore the clinical characteristics and the drug resistance in our hospital and to provide the scientific evidence for clinically reasonable use of antibiotics. Methods VITEK-2 Compact was used to identify the clinical strains. WHONET 5.6 software was used to analyze the clinical isolates of pathogens (Jan 2015- Dec 2015 ). Results A total of 2924 non-repetitive messages of bacteria were collected in 2015. Among them, the prevalence of gram-negative bacteria was 69.6%（2036/2924）and gram-positive bacteria was 30.4%.（888/2924）. Most of the bacteria were isolated from sputum，urine，blood and secretion specimens. Departments of ICU was the main endemic area of bacteria，followed by clinic service，general surgery，urology surgery and respiratory .For Escherichia coli and klebsiella pneumoniae，the drug resistance of ESBLs positive Escherichia coli and klebsiella pneumoniae is more serious than the ESBLs negative Escherichia coli and klebsiella pneumoniae. For gram-negative bacteria, the Carbapenem-resistace of Acinetobacter baumannii and klebsiella pneumonia was still serious. For gram-positive bacteria, the resistance rate of methicillin-resistant staphylococcus(MRS) is higher than that of methicillin sensitive staphylococcus(MSS). Conclusion The bacterial drug-resistance was still serious issue in the clinical setting in the year of 2015. Monitoring antimicrobial resistance have important significance to control infection and guide clinical rational drug use.

Key words: 【key words】Bacteria, Clinical characteristic, Drug-resistance, resistance surveillance