Abstract: Though intravertebral anesthesia has numerous potential advantages in some surgeries, unfortunately it has numerous potential disadvantages, such as potential hypotension due to sympathetic block, and potential toxicity, nausea and vomiting and so on. Recent experiments showed that the combined application of intrathecal opioids and regional anesthetics can produce obvious synergistic effect- extremely low concentrations of regional anesthetics combined with opioids greatly enhance the analgesic effect. There are reports of opioid analgesics administered combined with intravertebral can be added for nerve block and in regional anesthetic which can prolong the duration of sensory and motor nerve block, enhance the regional anesthetic analgesic effect during operation, prolong the time of postoperative analgesia, and decrease the dose of regional anesthetic. Thus, in an attempt to avoid unpleasant side-effects associated with intravertebral anesthesia, opioid analgesics administered intravertebrally has been offered to patients as an additive to intravertebral anesthesia. Binding to its receptor，opioids can stimulate the release of endogenous opioid peptides, it can also inhibit the sympathetic nerve to reduce the release of norepinephrine，so it can enhance the threshold of body pain．

Key words: Opioid Analgesics, Regional Anesthetic, Intravertebral Anesthesia