TLR4/MyD88信号通路在卵巢癌紫杉醇化疗抵抗中的研究进展

doi:10.3969/j.issn.2095-378X.2019.01.014

Abstract

Abstract: Gynecological malignancies are one of the important diseases endangering women's health.Ovarian cancer is the most malignant tumour, ranking first in gynecological malignancy death.About 70%-80% of the patients are diagnosed as stage III-IV at their initial visit.Although the treatment methods are ever improving and updating, 80% of the ovarian cancer patients still have a recurrence within one to two years, and the 5-year total survival rate in patients with stage IV ovarian cancer according to International Federation of Gynecology and Obstetrics (FIGO) staging criteria is less than 5%.Studies have shown that paclitaxel, a first-line treatment for immunogenic ovarian cancer, is only 30% effective.Paclitaxel is one of the main ligands of toll-like receptor 4 (TLR4).TLR4 is expressed in all ovarian tissues, and its staining intensity is significantly increased in malignant tumor cells.MyD88 expression is observed in 77.1% ovarian tissues, but not expressed in normal ovarian epithelial tissues, so the high expression of MyD88 is an independent prognostic factor for tumor-free survival and total survival of ovarian carcinoma patients.In epithelial ovarian carcinoma patients with positive MyD88, the activation of TLR4/MyD88-dependent pathway mediates chemoresistance and tumor progression by inflammatory cytokine stimulation, apoptosis inhibition, and immunosuppression, and even promotes cancer cell growth.

Key words: TLR4/MyD88 signaling pathway, Ovarian cancer, Chemoresistance, Negative regulation, Immunosuppression

CLC Number:

C320.3110

WANG Anfeng, PAN Chen, TONG Xiaowen. Research progress on TLR4/MyD88 signaling pathway in paclitaxel-resistant ovarian carcinoma[J]. Surgical Research and New Technique, 2019, 8(1): 49-53.

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Research progress on TLR4/MyD88 signaling pathway in paclitaxel-resistant ovarian carcinoma

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