Abstract: Objective To explore the relationship of clinical significance and prognosis between patients with mild traumatic brain injury (mTBI) and glial fibrillary acidic protein breakdown products(GFAP-BDPs) change.Methods Detected by ELISA in 47 cases of mild head injury patients and 20 healthy subjects serum GFAP-BDPs content,and the Results were compared.Comparison the serum concentrations of GFAP-BDPs between the 27 cases of head CT negative mTBI patients and the 20 cases of head CT positive mTBI patients.The relationship was assessed between the GOS-E score of mTBI patient after 6 months and the concentrations of GFAP-BDPs in the serum of patients.Results Serum of patients with mild head injury GFAP-BDPs were significantly higher than that of the control group (P<0.05).Conclusion GFAP-BDPs serum can be used as diagnostic biomarkers of mTBI,It has a certain accuracy that serum GFAP-BDPs levels can identify patients with positive and negative head CT; The higher levels of serum GFAP-BDPs worse prognosis.

Key words: GFAP-BDPs, mTBI, GOS-E