腹腔镜切开取胚术中联合甲氨蝶呤治疗异位妊娠的临床效果及对预后的影响评价

doi:10.3969/j.issn.2095-378X.2022.03.010

Abstract

Abstract: Objective To investigate the clinical effect of laparoscopic surgery combined with methotrexate on ectopic pregnancy and prognosis. Methods A total of 90 cases of ectopic pregnancy who were admitted to Yangdong District People's Hospital of Yangjiang City from April 2018 to March 2021 were selected and divided into a control group and an observation group （45 cases each group） by random number table method. The control group received laparoscopic treatment, and the observation group received laparoscopic treatment in combination with methotrexate. Treatment effect, blood human chorionic gonadotropin （β-HCG） recovery time, postoperative abdominal pain rate, tubal patency, and hospital stay were observed in the two groups. At 12 months of follow up, natural pregnancy rate and recurrence rate of ectopic pregnancy were compared between the two groups. Results The total effective rate of curative effect in the observation group was higher than that in the control group （P<0.05）. The β-HCG recovery time, postoperation abdominal pain rate, and length of hospital stay in the observation group were lower than those in the control group, and the tubal patency was higher （P<0.05）. After 12 months of follow-up, the natural pregnancy rate was higher and the recurrence rate of ectopic pregnancy was lower in the observation group than in the control group （P<0.05）. Conclusion Laparoscopic surgery combined with methotrexate in treating ectopic pregnancy is more effective than laparoscopic surgery only. It can shorten the time for blood β-HCG concentration to return to normal level, reduce postoperative abdominal pain rate, and improve the rate of tubal recanalization. The follow-up results suggest that laparoscopic surgery combined with methotrexate in the treatment of ectopic pregnancy can help improve natural pregnancy rate and reduce the recurrence rate of ectopic pregnancy.

Key words: Ectopic pregnancy, Laparoscopy, Methotrexate, Efficacy, Human chorionic gonadotropin, Pregnancy, Recurrence

CLC Number:

R713

LIU Yi'en, WU Xiajun, TAN Fuxian. Clinical effect of laparoscopic surgery combined with methotrexate on ectopic pregnancy and prognosis[J]. Surgical Research and New Technique, 2022, 11(3): 183-186.

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Clinical effect of laparoscopic surgery combined with methotrexate on ectopic pregnancy and prognosis

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