Abstract: Objective To investigate the effect of remazolam benzenesulfonate anesthesia on hemodynamics in elderly patients undergoing painless gastroenteroscopy. Methods A total of 100 patients with painless gastroenteroscopy in Jin'an Distric Hospital of Fuzhou City from January 2021 to June 2023 were selected and divided into a control group and a study group with 50 cases in each group by random number table method. The control group was anesthetised with propofol + afentanil, and the study group was anesthetised with remazolam benzenesulfonate + afentanil. The hemodynamics and anesthesia quality of the two groups were compared at different time points [before anesthesia induction （T0）, 3 min of anesthesia induction （T1）, 10 min of anesthesia induction （T2）, and recovery （T3）]. Results Compared with T0, the heart rate, blood oxygen saturation, and mean arterial pressure of patients at T1-T3 decreased, but the three indicators of patients in the study group decreased less than those of the control group, and at T3, the three indicators of patients in the two groups rebounded （P<0.05）. The onset time of induction in the study group was longer than that in the control group, and the time of awakening and leaving the surgery room was shorter than that in the control group （P<0.05）. Conclusion Actively implementing remazolam benzenesulfonate + alfentanil anesthesia during painless gastroenteroscopy in elderly patients can achieve ideal anesthesia effects and have less impacts on hemodynamics.

Key words: Painless gastroenteroscopy, Remazolam benzenesulfonate, Hemodynamics, Anesthesia quality