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Review

Research progress on application of exosomes in kidney transplantation

  • HUANG Yushi ,
  • GUO Peixin ,
  • MA Liyun ,
  • HUI Jialiang
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  • 1. Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China;
    2. Department of Organ Transplant, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China

Received date: 2024-05-13

  Online published: 2024-10-17

Abstract

As one of the best treatments for end-stage renal disease, kidney transplantation has been widely carried out worldwide. However, due to the problems of immune rejection and postoperative complications in kidney transplantation, how to improve the success rate of kidney transplantation and prolong the life of transplanted kidney is still a major problem. Exosomes participate in the whole process of kidney transplantation, including preoperative diagnosis, postoperative immune rejection and other complications, because of their information transmission and material transport functions. This article expounded the important roles of exosomes in kidney transplantation from three aspects of immune rejection, immunosuppressant toxicity, and other post transplant complications, in order to provide new ideas for clinical diagnosis and treatment.

Cite this article

HUANG Yushi , GUO Peixin , MA Liyun , HUI Jialiang . Research progress on application of exosomes in kidney transplantation[J]. Surgical Research and New Technique, 2024 , 13(3) : 243 -248 . DOI: 10.3969/j.issn.2095-378X.2024.03.015

References

[1] Augustine J.Kidney transplant: new opportunities and challenges[J]. Cleve Clin J Med, 2018, 85(2): 138-144.
[2] Johnstone RM, Bianchini A, Teng K.Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions[J]. Blood, 1989,74(5): 1844-1851.
[3] Stoorvogel W, Kleijmeer MJ, Geuze HJ, et al.The biogenesis and functions of exosomes[J]. Traffic, 2002, 3(5): 321-330.
[4] Staals RH, Pruijn GJ.The human exosome and disease[J]. Adv Exp Med Biol, 2011, 702(33): 132-142.
[5] Menjivar NG, Oropallo J, Gebremedhn S, et al.MicroRNA nano-shuttles: engineering extracellular vesicles as a cutting-edge biotechnology platform for clinical use in therapeutics[J]. Biol Proced Online, 2024, 26(1): 14.
[6] Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes[J]. Science, 2020, 367(6478): 69-77.
[7] Menon MC, Murphy B, Heeger PS.Moving biomarkers toward clinical implementation in kidney transplantation[J]. J Am Soc Nephrol, 2017, 28(3): 735-747.
[8] Gonzalez-Nolasco B, Wang M, Prunevieille A, et al.Emerging role of exosomes in allorecognition and allograft rejection[J]. Curr Opin Organ Transplant, 2018, 23(1): 22-27.
[9] Lim JH, Lee CH, Kim KY, et al.Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: a cross-sectional study[J]. PLoS One, 2018, 13(9): e204204.
[10] Park J, Lin HY, Assaker JP, et al.Integrated kidney exosome analysis for the detection of kidney transplant rejection[J]. ACS Nano, 2017, 11(11): 11041-11046.
[11] Chancharoenthana W, Traitanon O, Leelahavanichkul A, et al.Molecular immune monitoring in kidney transplant rejection: a state-of-the-art review[J]. Front Immunol, 2023,14(14): 117-136.
[12] Cuadrado-Payán E, Ramírez-Bajo MJ, Bañón-Maneus E, et al.Physiopathological role of extracellular vesicles in alloimmunity and kidney transplantation and their use as biomarkers[J]. Front Immunol, 2023, 14(14): 108-116.
[13] Romero-García N, Huete-Acevedo J, Mas-Bargues C, et al.Extracellular vesicles: the tuture of diagnosis in solid organ transplantation?[J]. Int J Mol Sci, 2023, 24(6): 1-21.
[14] Zhang H, Huang E, Kahwaji J, et al.Plasma exosomes from HLA-sensitized didney transplant recipients contain mRNA transcripts which predict development of antibody-mediated rejection[J]. Transplantation, 2017, 101(10): 2419-2428.
[15] Sharma M, Ravichandran R, Bansal S, et al.Tissue-associated self-antigens containing exosomes: role in allograft rejection[J]. Hum Immunol, 2018, 79(9): 653-658.
[16] El Fekih R, Hurley J, Tadigotla V, et al.Discovery and validation of a urinary exosome mRNA signature for the diagnosis of human kidney transplant rejection[J]. J Am Soc Nephrol, 2021, 32(4): 994-1004.
[17] Anglicheau D, Sharma VK, Ding R, et al.MicroRNA expression profiles predictive of human renal allograft status[J]. Proc Natl Acad Sci U S A, 2009, 106(13): 5330-5335.
[18] Millán O, Budde K, Sommerer C, et al.Urinary miR-155-5p and CXCL10 as prognostic and predictive biomarkers of rejection, graft outcome and treatment response in kidney transplantation[J]. Br J Clin Pharmacol, 2017, 83(12): 2636-2650.
[19] Quintairos L, Colom H, Millán O, et al.Early prognostic performance of miR155-5p monitoring for the risk of rejection: logistic regression with a population pharmacokinetic approach in adult kidney transplant patients[J]. PLoS One, 2021, 16(1): e245880.
[20] Carraro A, De Gaspari P, Antoniello B, et al.New insights into pediatric kidney transplant rejection biomarkers: tissue, plasma and urine microRNAs compared to protocol biopsy histology[J]. Int J Mol Sci, 2024, 25(3):1911.
[21] Jimenez-Coll V, Llorente S, Boix F, et al.Monitoring of serological, cellular and genomic biomarkers in transplantation, computational prediction models and role of cell-free DNA in transplant outcome[J]. Int J Mol Sci, 2023, 24(4): 3908.
[22] Monteiro MB, Santos-Bezerra DP, Pelaes TS, et al.MicroRNAs 1915-3p, 2861, and 4532 are associated with long-term renal function decline in type 1 diabetes[J]. Clin Chem, 2019, 65(11): 1458-1459.
[23] Chen Y, Han X, Sun Y, et al.A circulating exosomal microRNA panel as a novel biomarker for monitoring post-transplant renal graft function[J]. J Cell Mol Med, 2020, 24(20): 12154-12163.
[24] Sevcikova A, Fridrichova I, Nikolaieva N, et al.Clinical significance of microRNAs in hematologic malignancies and hematopoietic stem cell transplantation[J]. Cancers (Basel), 2023, 15(9): 2658.
[25] Ma A, Qi S, Wang Z, et al.Combined therapy of CD4CD25 regulatory T cells with low-dose sirolimus, but not calcineurin inhibitors, preserves suppressive function of regulatory T cells and prolongs allograft survival in mice. Int Immunopharmacol, 2009, 9(5): 553-563.
[26] Pêche H, Renaudin K, Beriou G, et al.Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model[J]. Am J Transplant, 2006, 6(7): 1541-1550.
[27] Bracamonte-Baran W, Florentin J, Zhou Y, et al.Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance[J]. Proc Natl Acad Sci U S A, 2017, 114(5): 1099-1104.
[28] Pêche H, Heslan M, Usal C, et al.Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection[J]. Transplantation, 2003, 76(10): 1503-1510.
[29] Ott LC, Cuenca AG.Innate immune cellular therapeutics in transplantation[J]. Front Transplant, 2023, 2(2): 1067512.
[30] Du YM, Zhuansun YX, Chen R, et al.Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma[J]. Exp Cell Res, 2018, 363(1): 114-120.
[31] Pang XL, Wang ZG, Liu L, et al.Immature dendritic cells derived exosomes promotes immune tolerance by regulating T cell differentiation in renal transplantation[J]. Aging (Albany NY), 2019, 11(20): 8911-8924.
[32] Legaz I, Jimenez-Coll V, González-López R, et al.MicroRNAs as potential graft rejection or tolerance biomarkers and their dilemma in clinical routines behaving like devilish, angelic, or frightening elements[J]. Biomedicines, 2024, 12(1): 116.
[33] Ono Y, Perez-Gutierrez A, Nakao T, et al.Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance[J]. Hepatology, 2018, 67(4): 1499-1515.
[34] Benichou G, Wang M, Ahrens K, et al.Extracellular vesicles in allograft rejection and tolerance[J]. Cell Immunol, 2020,349(3): 104063.
[35] Dimuccio V, Ranghino A, Praticò BL, et al.Urinary CD133+ extracellular vesicles are decreased in kidney transplanted patients with slow graft function and vascular damage[J]. PLoS One, 2014, 9(8): e104490.
[36] Wang J, Li X, Wu X, et al.Expression profiling of exosomal miRNAs derived from the peripheral blood of kidney recipients with DGF using high-throughput sequencing[J]. Biomed Res Int, 2019, 2019(19): 1759697.
[37] Esteva-Font C, Guillén-Gómez E, Diaz JM, et al.Renal sodium transporters are increased in urinary exosomes of cyclosporine-treated kidney transplant patients[J]. Am J Nephrol, 2014, 39(6): 528-535.
[38] Capolongo G, Damiano S, Suzumoto Y, et al.Cyclosporin-induced hypertension is associated with the up-regulation of Na+-K+-2Cl- cotransporter (NKCC2)[J]. Nephrol Dial Transplant, 2024, 39(2): 297-304.
[39] Rojas-Vega L, Jiménez-Vega AR, Bazúa-Valenti S, et al.Increased phosphorylation of the renal Na+-Cl- cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort[J]. Am J Physiol Renal Physiol, 2015, 309(10): F836-F842.
[40] Curtis JJ.Hypertension and kidney transplantation[J]. Curr Opin Nephrol Hypertens, 1992, 1(1): 100-105.
[41] Ginevri F, Azzi A, Botti G, et al. La nefropatia associata all'infezione da polyoma virus BK dopo trapianto renale [Polyomavirus BK-associated nephropathy after kidney transplantation][J]. G Ital Nefrol, 2006, 23(6): 575-584. Italian.
[42] Martelli F, Wu Z, Delbue S, et al.BK polyomavirus microRNA levels in exosomes are modulated by non-coding control region activity and down-regulate viral replication when delivered to non-infected cells prior to infection[J]. Viruses, 2018, 10(9): 1-14.
[43] 黄海燕,肖漓,毕丽丽,等.肾移植术后病毒感染对外泌体研究影响的初步探索[J]. 中华医学杂志,2018,98(3):171-175.
[44] Kim MH, Lee YH, Seo JW, et al.Urinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients[J]. PLoS One, 2017, 12(12): e190068.
[45] Demey B, Bentz M, Descamps V, et al.BK polyomavirus bkv-miR-B1-5p: a stable micro-RNA to monitor active viral replication after kidney Transplantation[J]. Int J Mol Sci, 2022, 23(13): 7240.
[46] Jung SW, Cho WH, Seo JW, et al.Urine exosomal bkv-miR-B1-5p and BK virus nephropathy in kidney transplant recipients[J]. J Infect Dis, 2023, 227(10): 1185-1193.
[47] Alvarez S, Suazo C, Boltansky A, et al.Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation[J]. Transplant Proc, 2013, 45(10): 3719-3723.
[48] Roest HP, Ooms L, Gillis A, et al.Cell-free microRNA miR-505-3p in graft preservation fluid is an independent predictor of delayed graft function after kidney transplantation[J]. Transplantation, 2019, 103(2): 329-335.
[49] Li ZL, Lv LL, Tang TT, et al.HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation[J]. Kidney Int, 2019, 95(2): 388-404.
[50] Schauerte C, Hübner A, Rong S, et al.Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction[J]. Kidney Int, 2017, 92(3):646-656.
[51] Pipi E, Nayar S, Gardner DH, et al.Tertiary lymphoid structures: autoimmunity goes local[J]. Front Immunol, 2018,9(9): 1952.
[52] Dieudé M, Bell C, Turgeon J, et al.The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection[J]. Sci Transl Med, 2015, 7(318): 318-200.
[53] Dieudé M, Turgeon J, Karakeussian RA, et al.Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts[J]. Am J Transplant, 2020, 20(3): 726-738.
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