Objective To study the application effect of "three fixed" emergency mode in emergency rescue of patients with ectopic pregnancy and massive bleeding. Methods A total of 87 patients with ectopic pregnancy and massive bleeding admitted from January 2021 to May 2023 were selected and divided into a routine group （n=45） and a three fixed group （n=42）. The routine group received routine emergency nursing, while the three fixed group received “three fixed”emergency nursing.The evaluation indicators of emergency response timeliness, shock index, emergency nursing satisfaction of the two groups of patients were recorded, and the stress level of nurses before and after intervention, satisfaction of rescue medics, and skill scores of nursing staff were compared. Results The rescue time and total rescue and nursing time of the three fixed group were shorter than those of the routine group, and the total bleeding volume was lower （P<0.05）. The shock index of the three fixed group after intervention was significantly better than that of the routine group （P<0.05）. The nursing satisfaction of patients in the three fixed group was 97.62%, which was higher than 82.22% in the routine group （P<0.05）. The stress score of nurses in the routine group was higher than that in the three fixed group, while the satisfaction score of rescue medics was lower （P<0.05）. The basic abilities, professional first aid skills, and other skills of the nursing staff in the three fixed groups were significantly improved compared to the routine group（P<0.05）. Conclusion The implementation of the“three fixed” emergency mode for patients with ectopic pregnancy and massive bleeding can help improve the efficiency of medical staff's emergency response, relieve shock of patients, reduce the pressure of nursing staff on emergency response, and increase the satisfaction of patients and rescue medics, which is worthy of promotion.