Objective To study the efficacy advantages of flurbiprofen ester preemptive analgesia. Methods A total of 78 patients who underwent laparoscopic hysterectomy in Jin'an District Hospital of Fuzhou City from April 2023 to April 2024 were selected and divided into a control group （39 cases, with an equal amount of saline intervention） and an observation group （39 cases, with intravenous injection of 1 mg/kg flurbiprofen ester diluted to 10 mL of normal saline before anesthesia） by random number table method. Baseline data were comparable between the two groups. Analgesic effect and safety were compared between the two groups. Results The mean arterial pressure and heart rate of patients in the observation group were significantly lower than those of the control group at the time of intubation and extubation （P<0.05）. The pain scores [visual analogue scale （VAS） scores] of patients in the observation group were significantly lower than those of the control group at 1 min after extubation, 5 min after extubation, and the time of leaving the anesthesia room （P<0.05）. The level of inflammatory factors in peripheral blood of the observation group was significantly lower than that of the control group on postoperative day 1 （P<0.05）, and the level of T cell subsets was significantly higher （P<0.05）. The overall postoperative incidence rate of adverse reactions of patients in the observation group was significantly lower than that of the control group （P<0.05）. Conclusion The administration of flurbiprofen ester preemptive analgesia to laparoscopic hysterectomy patients is able to improve patients’ mean arterial pressure and heart rate, alleviate pain, reduce inflammatory factor levels, increase cellular immunity, and reduce the incidence of adverse reactions. It is worthy of clinical promotion.