Objective To explore the clinical effect of seamless nursing on patients undergoing kidney stone surgery using mind mapping. Methods A total of 256 postoperative patients with kidney stones from January 2021 to December 2023 were selected and randomly divided into an observation group and a control group by random number table method, with 128 cases in each group. The control group received routine care, while the observation group received seamless care based on mind mapping. Clinical indicators, complications, quality of life, psychological resilience, and nursing evaluation were compared between the two groups. Results The five indicators including operation time in the observation group were lower than those in the control group （P<0.05）. The proportion of patients with five complications such as wound infection in the observation group was 2.34%, which was lower than that in the control group （8.59%）（P<0.05）. The eight scores of the Medical Outcomes Study 36-Item Short-Form Health Survey （SF-36） in the observation group were higher than those in the control group （P<0.05）. The three scores of the Connor-Davids on Resilience Scale （CD-RISC） in both the observation group and the control group increased after nursing compared with those before nursing, and the observation group was higher than the control group （P<0.05）. The five evaluation scores including basic nursing in the observation group were higher than those in the control group （P<0.05）. Conclusion The method for the observation group can accelerate the restoration of various indicators to normal after surgery, reduce the occurrence of complications, and improve overall quality of life, which is worthy of promotion and application.