Objective To evaluate the effect of nursing quality management on infection control in digestive endoscopic therapy. Methods A total of 50 patients from January to December 2023 were selected and divided into an observation group （25 cases） and a control group （25 cases） by random number table method. The patients in the control group received routine nursing intervention, and the patients in the observation group received nursing quality management on the basis of routine nursing. The infection rate and the pass rates of digestive endoscopy-related infection monitoring indicators after designed digestive endoscopic treatment were compared between the two groups. Results The infection rate in the observation group （0） was significantly lower than that in the control group （16%） after nursing quality management （P<0.05）. The pass rates of digestive endoscopy-related infection monitoring indicators in the observation group were significantly higher than those in the control group（P<0.05）. Conclusion The application of nursing quality management in digestive endoscopic therapy can reduce the infection rate of patients and further improve the efficiency and quality of medical intervention, which is worthy of promotion.