Objective To evaluate the effects of enhanced enteral nutrition combined with glutamine （Gln） on therapeutic outcomes in patients with severe acute pancreatitis （SAP） through a meta-analysis. Methods Relevant studies on enteral nutrition combined with Gln in SAP patients were retrieved from databases including China National Knowledge Infrastructure （CNKI）， Wanfang Data， VIP， National Science and Technology Digital Library， PubMed， Cochrane Library， Embase， and Google Scholar， with a search timeframe spanning from the inception of each database to October 8， 2021. Two independent reviewers screened the literature based on predefined inclusion and exclusion criteria， focusing on randomized controlled trials （RCTs） in which the experimental group received enhanced enteral nutrition combined with Gln， and the control group received standard enteral nutrition alone. The quality of included studies was assessed using the Cochrane Handbook for Systematic Reviews， and statistical analysis was performed using RevMan 5.4 software. Results Nine studies involving 601 patients （298 in the experimental group and 303 in the control group） were included. Meta-analysis results demonstrated that， compared to the control group， the experimental group exhibited significantly lower post-treatment levels of hypersensitive C-reactive protein （hs-CRP） （MD=-1.37， 95%CI： -1.89， -0.86； P<0.05） and interleukin-6 （IL-6） （MD=-5.00， 95%CI： -6.85， -3.14； P<0.05）， as well as significantly higher levels of serum albumin （MD=3.46， 95%CI： 2.26， 4.65； P<0.05） and serum prealbumin （MD=42.15， 95%CI： 21.46， 62.84； P<0.05）. Additionally， the total hospital stay was significantly shorter in the experimental group （MD=-8.86， 95%CI： -17.06， -0.66； P<0.05）. Conclusion Enhanced enteral nutrition combined with Gln significantly improves inflammatory and nutritional indicators in SAP patients and reduces the total hospital stay. Therefore， enhanced enteral nutrition combined with Gln is recommended for SAP patients to consolidate therapeutic efficacy.
WANG Liting
,
QIAO Na
,
CHANG Shulin
,
LU Yan
,
LIU Jingli
. Meta-analysis on efficacy of enhanced enteral nutrition combined with glutamine in patients with severe acute pancreatitis[J]. Surgical Research and New Technique, 2025
, 14(1)
: 23
-30
.
DOI: 10.3969/j.issn.2095-378X.2025.01.005
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