Objective To implement a quality control circle activity addressing the issue of excessive time spent on instrument post-processing after surgery, with the aim of improving work efficiency, reducing unnecessary repetitive steps, and shortening instrument post-processing time. Methods A quality control circle team was established on the theme of shortening the post-processing time of surgical instruments. The team developed an activity plan, analyzed the underlying causes for the lengthy post-processing of instruments, formulated corresponding countermeasures, and put them into practice. Results Through the effective management of the quality control circle, the team members’ abilities were improved, and the post-processing time of surgical instruments between August and September 2024 were significantly reduced. Conclusion The quality control circle activity has shortened the post-processing time of surgical instruments, improved the work efficiency of the supply room, and enhanced various abilities of circle members, which provides logistical support for the hospital's plan to increase surgeries in the future.